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Universiteit Leiden

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2008

Clinckers, R., Smolders, I, Michotte, Y., Ebinger, G., Danhof, M., Voskuyl, R.A., Della Pasqua, O. , Impact of efflux transporters and of seizures on the pharmacokinetics of oxcarbazepine metabolite in the rat brain, Br J Pharmacol, vol. 155, no. 7, pp. 1127-38.

2007

Yassen, A., Kan, J., Olofsen, E., Suidgeest, E., Dahan, A., Danhof, M. , Pharmacokinetic-pharmacodynamic modeling of the respiratory depressant effect of norbuprenorphine in rats, J Pharmacol Exp Ther, vol. 321, no. 2, pp. 598-607.

2006

Nugroho, A.K., Romeijn, S.G., Zwier, R., de Vries, J.B., Dijkstra, D., Wikstrom, H., Della-Pasqua, O., Danhof, M., Bouwstra, J.A. , Pharmacokinetics and pharmacodynamics analysis of transdermal iontophoresis of 5-OH-DPAT in rats: in vitro-in vivo correlation, J Pharm Sci, vol. 95, no. 7, pp. 1570-85.

2005

Schaddelee, M.P., Collins, S.D., DeJongh, J., de Boer, A.G., Ijzerman, A.P., Danhof, M. , Pharmacokinetic/pharmacodynamic modelling of the anti-hyperalgesic and anti-nociceptive effect of adenosine A1 receptor partial agonists in neuropathic pain, Eur J Pharmacol, vol. 514, no. 2-3, pp. 131-40.

Nugroho, A.K., Li, L., Dijkstra, D., Wikstrom, H., Danhof, M., Bouwstra, J.A. , Transdermal iontophoresis of the dopamine agonist 5-OH-DPAT in human skin in vitro, J Control Release, vol. 103, no. 2, pp. 393-403.

Schaddelee, M.P., Read, K.D., Cleypool, C.G., Ijzerman, A.P., Danhof, M., de Boer, A.G. , Brain penetration of synthetic adenosine A1 receptor agonists in situ: role of the rENT1 nucleoside transporter and binding to blood constituents, Eur J Pharm Sci, vol. 24, no. 1, pp. 59-66.

Swart, E.L., de Jongh, J., Zuideveld, K.P., Danhof, M., Thijs, L.G., van Strack Schijndel, R.J. , Population pharmacokinetics of lorazepam and midazolam and their metabolites in intensive care patients on continuous venovenous hemofiltration, Am J Kidney Dis, vol. 45, no. 2, pp. 360-71.

2004

Schaddelee, M.P., Dejongh, J., Collins, S.D., de Boer, A.G., Ijzerman, A.P., Danhof, M. , Population pharmacokinetic-pharmacodynamic modelling of the anti-hyperalgesic effect of 5'deoxy-N6-cylopentyladenosine in the mononeuropathic rat, Eur J Pharmacol, vol. 504, no. 1-2, pp. 7-15.

Schaddelee, M.P., Groenendaal, D., DeJongh, J., Cleypool, C.G., AP, I.J., De Boer, A.G., Danhof, M. , Population pharmacokinetic modeling of blood-brain barrier transport of synthetic adenosine A1 receptor agonists, J Pharmacol Exp Ther, vol. 311, no. 3, pp. 1138-46.

2003

Bueters, T.J., van Duivenvoorde, L.M., Danhof, M., AP, I.J., van Helden, H.P. , Cyclopentyladenosine and some of its low-efficacy derivatives inhibit striatal synaptosomal release of acetylcholine to a similar degree, Eur J Pharmacol, vol. 481, no. 2-3, pp. 141-6.

Schaddelee, M.P., Voorwinden, H.L., Groenendaal, D., Hersey, A., Ijzerman, A.P., Danhof, M., De Boer, A.G. , Blood-brain barrier transport of synthetic adenosine A1 receptor agonists in vitro: structure transport relationships, Eur J Pharm Sci, vol. 20, no. 3, pp. 347-56.

Bueters, T.J., van Helden, H.P., AP, I.J., Danhof, M. , Low efficacy adenosine A1 agonists inhibit striatal acetylcholine release in rats improving central selectivity of action, Neurosci Lett, vol. 343, no. 1, pp. 57-61.

Schaddelee, M.P., Voorwinden, H.L., van Tilburg, E.W., Pateman, T.J., Ijzerman, A.P., Danhof, M., de Boer, A.G. , Functional role of adenosine receptor subtypes in the regulation of blood-brain barrier permeability: possible implications for the design of synthetic adenosine derivatives, Eur J Pharm Sci, vol. 19, no. 1, pp. 13-22.

Bueters, T.J., Joosen, M.J., van Helden, H.P., Ijzerman, A.P., Danhof, M. , Adenosine A1 receptor agonist N6-cyclopentyladenosine affects the inactivation of acetylcholinesterase in blood and brain by sarin, J Pharmacol Exp Ther, vol. 304, no. 3, pp. 1307-13.

2002

Bueters, T.J., Groen, B., Danhof, M., AP, I.J., Van Helden, H.P. , Therapeutic efficacy of the adenosine A1 receptor agonist N6-cyclopentyladenosine (CPA) against organophosphate intoxication, Arch Toxicol, vol. 76, no. 11, pp. 650-6.

Swart, E.L., van der Hoven, B., Groeneveld, A.B., Touw, D.J., Danhof, M. , Correlation between midazolam and lignocaine pharmacokinetics and MEGX formation in healthy volunteers, Br J Clin Pharmacol, vol. 53, no. 2, pp. 133-9.

Zuideveld, K.P., Rusic-Pavletic, J., Maas, H.J., Peletier, L.A., Van der Graaf, P.H., Danhof, M. , Pharmacokinetic-pharmacodynamic modeling of buspirone and its metabolite 1-(2-pyrimidinyl)-piperazine in rats, J Pharmacol Exp Ther, vol. 303, no. 3, pp. 1130-7.

2000

Garrido, M., Gubbens-Stibbe, J., Tukker, E., Cox, E., von Frijtag, J., Kunzel, D., A, I.J., Danhof, M., van der Graaf, P.H. , Pharmacokinetic-pharmacodynamic analysis of the EEG effect of alfentanil in rats following beta-funaltrexamine-induced mu-opioid receptor "knockdown" in vivo, Pharm Res, vol. 17, no. 6, pp. 653-9.

1999

Tuk, B., van Oostenbruggen, M.F., Herben, V.M., Mandema, J.W., Danhof, M. , Characterization of the pharmacodynamic interaction between parent drug and active metabolite in vivo: midazolam and alpha-OH-midazolam, J Pharmacol Exp Ther, vol. 289, no. 2, pp. 1067-74.

Van der Graaf, P.H., Van Schaick, E.A., Visser, S.A., De Greef, H.J., Ijzerman, A.P., Danhof, M. , Mechanism-based pharmacokinetic-pharmacodynamic modeling of antilipolytic effects of adenosine A(1) receptor agonists in rats: prediction of tissue-dependent efficacy in vivo, J Pharmacol Exp Ther, vol. 290, no. 2, pp. 702-9.

1998

van Schaick, E.A., Zuideveld, K.P., Tukker, H.E., Langemeijer, M.W., Ijzerman, A.P., Danhof, M. , Metabolic and cardiovascular effects of the adenosine A1 receptor agonist N6-(p-sulfophenyl)adenosine in diabetic Zucker rats: influence of the disease on the selectivity of action, J Pharmacol Exp Ther, vol. 287, no. 1, pp. 21-30.

van Schaick, E.A., Tukker, H.E., Roelen, H.C., AP, I.J., Danhof, M. , Selectivity of action of 8-alkylamino analogues of N6-cyclopentyladenosine in vivo: haemodynamic versus anti-lipolytic responses in rats, Br J Pharmacol, vol. 124, no. 3, pp. 607-18.

1997

Van der Graaf, P.H., Danhof, M. , Analysis of drug-receptor interactions in vivo: a new approach in pharmacokinetic-pharmacodynamic modelling, Int J Clin Pharmacol Ther, vol. 35, no. 10, pp. 442-6.

van Schaick, E.A., de Greef, H.J., Langemeijer, M.W., Sheehan, M.J., AP, I.J., Danhof, M. , Pharmacokinetic-pharmacodynamic modelling of the anti-lipolytic and anti-ketotic effects of the adenosine A1-receptor agonist N6-(p-sulphophenyl)adenosine in rats, Br J Pharmacol, vol. 122, no. 3, pp. 525-33.

van der Geest, R., Kruger, P., Gubbens-Stibbe, J.M., van Laar, T., Bodde, H.E., Danhof, M. , Assay of R-apomorphine, S-apomorphine, apocodeine, isoapocodeine and their glucuronide and sulfate conjugates in plasma and urine of patients with Parkinson's disease, J Chromatogr B Biomed Sci Appl, vol. 702, no. 1-2, pp. 131-41.

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