LACDR

Universiteit Leiden

List
Filter

Found 20 results. Export: Tagged | XML

Filters: keyword is Midazolam [Clear All Filters]

2006

Peeters, M.Y., Prins, S.A., Knibbe, C.A., Dejongh, J., Mathot, R.A., Warris, C., van Schaik, R.H., Tibboel, D., Danhof, M. , Pharmacokinetics and pharmacodynamics of midazolam and metabolites in nonventilated infants after craniofacial surgery, Anesthesiology, vol. 105, no. 6, pp. 1135-46.

2003

Visser, S.A., Huntjens, D.R., van der Graaf, P.H., Peletier, L.A., Danhof, M. , Mechanism-based modeling of the pharmacodynamic interaction of alphaxalone and midazolam in rats, J Pharmacol Exp Ther, vol. 307, no. 2, pp. 765-75.

2002

Tuk, B., van Gool, T., Danhof, M. , Mechanism-based pharmacodynamic modeling of the interaction of midazolam, bretazenil, and zolpidem with ethanol, J Pharmacokinet Pharmacodyn, vol. 29, no. 3, pp. 235-50.

Swart, E.L., van der Hoven, B., Groeneveld, A.B., Touw, D.J., Danhof, M. , Correlation between midazolam and lignocaine pharmacokinetics and MEGX formation in healthy volunteers, Br J Clin Pharmacol, vol. 53, no. 2, pp. 133-9.

1999

Tuk, B., van Oostenbruggen, M.F., Herben, V.M., Mandema, J.W., Danhof, M. , Characterization of the pharmacodynamic interaction between parent drug and active metabolite in vivo: midazolam and alpha-OH-midazolam, J Pharmacol Exp Ther, vol. 289, no. 2, pp. 1067-74.

Cleton, A., Mazee, D., Voskuyl, R.A., Danhof, M. , Rate of change of blood concentrations is a major determinant of the pharmacodynamics of midazolam in rats, Br J Pharmacol, vol. 127, no. 1, pp. 227-35.

1998

Cleton, A., Voskuyl, R.A., Danhof, M. , Adaptive changes in the pharmacodynamics of midazolam in different experimental models of epilepsy: kindling, cortical stimulation and genetic absence epilepsy, Br J Pharmacol, vol. 125, no. 4, pp. 615-20.

Tuk, B., Herben, V.M., Mandema, J.W., Danhof, M. , Relevance of arteriovenous concentration differences in pharmacokinetic-pharmacodynamic modeling of midazolam, J Pharmacol Exp Ther, vol. 284, no. 1, pp. 202-7.

1995

Hoyo-Vadillo, C., Mandema, J.W., Danhof, M. , Pharmacodynamic interaction between midazolam and a low dose of ethanol in vivo, Life Sci, vol. 57, no. 4, pp. 325-33.

1993

Van Steveninck, A.L., Mandema, J.W., Tuk, B., Van Dijk, J.G., Schoemaker, H.C., Danhof, M., Cohen, A.F. , A comparison of the concentration-effect relationships of midazolam for EEG-derived parameters and saccadic peak velocity, Br J Clin Pharmacol, vol. 36, no. 2, pp. 109-15.

1992

Hovinga, S., Stijnen, A.M., Langemeijer, M.W., Mandema, J.W., van Bezooijen, C.F., Danhof, M. , Pharmacokinetic-EEG effect relationship of midazolam in aging BN/BiRij rats, Br J Pharmacol, vol. 107, no. 1, pp. 171-7.

Mandema, J.W., Tuk, B., van Steveninck, A.L., Breimer, D.D., Cohen, A.F., Danhof, M. , Pharmacokinetic-pharmacodynamic modeling of the central nervous system effects of midazolam and its main metabolite alpha-hydroxymidazolam in healthy volunteers, Clin Pharmacol Ther, vol. 51, no. 6, pp. 715-28.

Mandema, J.W., Tukker, E., Danhof, M. , In vivo characterization of the pharmacodynamic interaction of a benzodiazepine agonist and antagonist: midazolam and flumazenil, J Pharmacol Exp Ther, vol. 260, no. 1, pp. 36-44.

Mandema, J.W., Kuck, M.T., Danhof, M. , In vivo modeling of the pharmacodynamic interaction between benzodiazepines which differ in intrinsic efficacy, J Pharmacol Exp Ther, vol. 261, no. 1, pp. 56-61.

1991

Aarons, L., Mandema, J.W., Danhof, M. , A population analysis of the pharmacokinetics and pharmacodynamics of midazolam in the rat, J Pharmacokinet Biopharm, vol. 19, no. 5, pp. 485-96.

Mandema, J.W., Tukker, E., Danhof, M. , Pharmacokinetic-pharmacodynamic modelling of the EEG effects of midazolam in individual rats: influence of rate and route of administration, Br J Pharmacol, vol. 102, no. 3, pp. 663-8.

Breimer, L.T., Burm, A.G., Danhof, M., Hennis, P.J., Vletter, A.A., de Voogt, J.W., Spierdijk, J., Bovill, J.G. , Pharmacokinetic-pharmacodynamic modelling of the interaction between flumazenil and midazolam in volunteers by aperiodic EEG analysis, Clin Pharmacokinet, vol. 20, no. 6, pp. 497-508.

Koopmans, R., Dingemanse, J., Danhof, M., Horsten, G.P., van Boxtel, C.J. , The influence of dosage time of midazolam on its pharmacokinetics and effects in humans, Clin Pharmacol Ther, vol. 50, no. 1, pp. 16-24.

1990

Breimer, L.T., Hennis, P.J., Burm, A.G., Danhof, M., Bovill, J.G., Spierdijk, J., Vletter, A.A. , Quantification of the EEG effect of midazolam by aperiodic analysis in volunteers. Pharmacokinetic/pharmacodynamic modelling, Clin Pharmacokinet, vol. 18, no. 3, pp. 245-53.

1988

Koopmans, R., Dingemanse, J., Danhof, M., Horsten, G.P., van Boxtel, C.J. , Pharmacokinetic-pharmacodynamic modeling of midazolam effects on the human central nervous system, Clin Pharmacol Ther, vol. 44, no. 1, pp. 14-22.

LACDR