Filters: keyword is Kinetics [Clear All Filters]
- 2008
The exploration of rotenone as a toxin for inducing Parkinson's disease in rats, for application in BBB transport and PK-PD experiments,
J Pharmacol Toxicol Methods, vol. 57, no. 2, pp. 114-30.
Mechanistic model for the acute effect of fluvoxamine on 5-HT and 5-HIAA concentrations in rat frontal cortex,
Eur J Pharm Sci, vol. 33, no. 3, pp. 217-29.
Disease severity is a major determinant for the pharmacodynamics of propofol in critically ill patients,
Clin Pharmacol Ther, vol. 83, no. 3, pp. 443-51.
Population pharmacokinetic modelling of the enterohepatic recirculation of diclofenac and rofecoxib in rats,
Br J Pharmacol, vol. 153, no. 5, pp. 1072-84.
Pilot study on the influence of liver blood flow and cardiac output on the clearance of propofol in critically ill patients,
Eur J Clin Pharmacol, vol. 64, no. 3, pp. 329-34.
Pharmacokinetic/pharmacodynamic modelling of the EEG effects of opioids: the role of complex biophase distribution kinetics,
Eur J Pharm Sci, vol. 34, no. 2-3, pp. 149-63.
Pharmacokinetic-pharmacodynamic modelling of fluvoxamine 5-HT transporter occupancy in rat frontal cortex,
Br J Pharmacol, vol. 154, no. 6, pp. 1369-78.
Amoxicillin pharmacokinetics in pregnant women with preterm premature rupture of the membranes,
Am J Obstet Gynecol, vol. 198, no. 1, pp. 108 e1-6.
Pharmacokinetic-pharmacodynamic modeling of the effectiveness and safety of buprenorphine and fentanyl in rats,
Pharm Res, vol. 25, no. 1, pp. 183-93.
Impact of efflux transporters and of seizures on the pharmacokinetics of oxcarbazepine metabolite in the rat brain,
Br J Pharmacol, vol. 155, no. 7, pp. 1127-38.
The influence of labour on the pharmacokinetics of intravenously administered amoxicillin in pregnant women,
Br J Clin Pharmacol, vol. 66, no. 6, pp. 866-74.
Extensions to the visual predictive check to facilitate model performance evaluation,
J Pharmacokinet Pharmacodyn, vol. 35, no. 2, pp. 185-202.
Mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling in translational drug research,
Trends Pharmacol Sci, vol. 29, no. 4, pp. 186-91.
Pharmacokinetic modeling of non-linear brain distribution of fluvoxamine in the rat,
Pharm Res, vol. 25, no. 4, pp. 792-804.
- 2007
Pharmacokinetics of penicillin G in infants with a gestational age of less than 32 weeks,
Antimicrob Agents Chemother, vol. 51, no. 10, pp. 3720-5.
Allometric scaling of pharmacodynamic responses: application to 5-Ht1A receptor mediated responses from rat to man,
Pharm Res, vol. 24, no. 11, pp. 2031-9.
Pharmacokinetic-pharmacodynamic modeling of the effect of fluvoxamine on p-chloroamphetamine-induced behavior,
Eur J Pharm Sci, vol. 32, no. 3, pp. 200-8.
Pharmacokinetic-pharmacodynamic modeling of the respiratory depressant effect of norbuprenorphine in rats,
J Pharmacol Exp Ther, vol. 321, no. 2, pp. 598-607.
Synergistic combinations of anticonvulsant agents: what is the evidence from animal experiments?,
Epilepsia, vol. 48, no. 3, pp. 412-34.
Pharmacokinetic-pharmacodynamic modelling of S(-)-atenolol in rats: reduction of isoprenaline-induced tachycardia as a continuous pharmacodynamic endpoint,
Br J Pharmacol, vol. 151, no. 3, pp. 356-66.
Reproducible and time-dependent modification of serum protein binding in Wistar Kyoto rats,
J Pharmacol Toxicol Methods, vol. 56, no. 1, pp. 72-8.
Influence of biophase distribution and P-glycoprotein interaction on pharmacokinetic-pharmacodynamic modelling of the effects of morphine on the EEG,
Br J Pharmacol, vol. 151, no. 5, pp. 713-20.
Population pharmacokinetic modelling of non-linear brain distribution of morphine: influence of active saturable influx and P-glycoprotein mediated efflux,
Br J Pharmacol, vol. 151, no. 5, pp. 701-12.
Application of the convection-dispersion equation to modelling oral drug absorption,
Bull Math Biol, vol. 69, no. 1, pp. 181-95.
Mechanism-based PK/PD modeling of the respiratory depressant effect of buprenorphine and fentanyl in healthy volunteers,
Clin Pharmacol Ther, vol. 81, no. 1, pp. 50-8.



