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Universiteit Leiden

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2008

Geldof, M., Freijer, J. I, van Beijsterveldt, L., Langlois, X., Danhof, M. , Pharmacokinetic-pharmacodynamic modelling of fluvoxamine 5-HT transporter occupancy in rat frontal cortex, Br J Pharmacol, vol. 154, no. 6, pp. 1369-78.

Geldof, M., Freijer, J., van Beijsterveldt, L., Danhof, M. , Pharmacokinetic modeling of non-linear brain distribution of fluvoxamine in the rat, Pharm Res, vol. 25, no. 4, pp. 792-804.

2007

Muller, A.E., DeJongh, J., Bult, Y., Goessens, W.H., Mouton, J.W., Danhof, M., van den Anker, J.N. , Pharmacokinetics of penicillin G in infants with a gestational age of less than 32 weeks, Antimicrob Agents Chemother, vol. 51, no. 10, pp. 3720-5.

Geldof, M., Freijer, J., van Beijsterveldt, L., Vermote, P.C., Megens, A.A., Danhof, M. , Pharmacokinetic-pharmacodynamic modeling of the effect of fluvoxamine on p-chloroamphetamine-induced behavior, Eur J Pharm Sci, vol. 32, no. 3, pp. 200-8.

Geldof, M., Freijer, J., van Beijsterveldt, L., Timmerman, P., Ahnaou, A., Drinkenburg, W.H., Danhof, M. , Population pharmacokinetic model of fluvoxamine in rats: utility for application in animal behavioral studies, Eur J Pharm Sci, vol. 30, no. 1, pp. 45-55.

Yassen, A., Olofsen, E., van Dorp, E., Sarton, E., Teppema, L., Danhof, M., Dahan, A. , Mechanism-based pharmacokinetic-pharmacodynamic modelling of the reversal of buprenorphine-induced respiratory depression by naloxone : a study in healthy volunteers, Clin Pharmacokinet, vol. 46, no. 11, pp. 965-80.

2004

Swart, E.L., Zuideveld, K.P., de Jongh, J., Danhof, M., Thijs, L.G., van Strack Schijndel, R.M. , Comparative population pharmacokinetics of lorazepam and midazolam during long-term continuous infusion in critically ill patients, Br J Clin Pharmacol, vol. 57, no. 2, pp. 135-45.

2002

Knibbe, C.A., Melenhorst-de Jong, G., Mestrom, M., Rademaker, C.M., Reijnvaan, A.F., Zuideveld, K.P., Kuks, P.F., van Vught, H., Danhof, M. , Pharmacokinetics and effects of propofol 6% for short-term sedation in paediatric patients following cardiac surgery, Br J Clin Pharmacol, vol. 54, no. 4, pp. 415-22.

1999

Cleton, A., Mazee, D., Voskuyl, R.A., Danhof, M. , Rate of change of blood concentrations is a major determinant of the pharmacodynamics of midazolam in rats, Br J Pharmacol, vol. 127, no. 1, pp. 227-35.

Cox, E.H., Langemeijer, M.W., Gubbens-Stibbe, J.M., Muir, K.T., Danhof, M. , The comparative pharmacodynamics of remifentanil and its metabolite, GR90291, in a rat electroencephalographic model, Anesthesiology, vol. 90, no. 2, pp. 535-44.

Van der Graaf, P.H., Van Schaick, E.A., Visser, S.A., De Greef, H.J., Ijzerman, A.P., Danhof, M. , Mechanism-based pharmacokinetic-pharmacodynamic modeling of antilipolytic effects of adenosine A(1) receptor agonists in rats: prediction of tissue-dependent efficacy in vivo, J Pharmacol Exp Ther, vol. 290, no. 2, pp. 702-9.

1998

Cox, E.H., Knibbe, C.A., Koster, V.S., Langemeijer, M.W., Tukker, E.E., Lange, R., Kuks, P.F., Langemeijer, H.J., Lie, A.H.L., Danhof, M. , Influence of different fat emulsion-based intravenous formulations on the pharmacokinetics and pharmacodynamics of propofol, Pharm Res, vol. 15, no. 3, pp. 442-8.

1997

van Schaick, E.A., de Greef, H.J., Ijzerman, A.P., Danhof, M. , Physiological indirect effect modeling of the antilipolytic effects of adenosine A1-receptor agonists, J Pharmacokinet Biopharm, vol. 25, no. 6, pp. 673-94.

Snoeck, E., Piotrovskij, V., Jacqmin, P., Lins, R.L., Van Peer, A., Danhof, M., Woestenborghs, R., Van Gool, R., Dupont, A.G., Heykants, J. , Population analysis of the non-linear red blood cell partitioning of draflazine following various infusion durations, Eur J Clin Pharmacol, vol. 53, no. 1, pp. 57-63.

1994

Vinks, A.A., Touw, D.J., Heijerman, H.G., Danhof, M., de Leede, G.P., Bakker, W. , Pharmacokinetics of ceftazidime in adult cystic fibrosis patients during continuous infusion and ambulatory treatment at home, Ther Drug Monit, vol. 16, no. 4, pp. 341-8.

1993

Stijnen, A.M., Hovinga, S., Langemeijer, M.W., Hoogerkamp, A., van Bezooijen, C.F., Danhof, M. , Increased sensitivity to the anticonvulsant effect of valproate in aging BN/BiRij rats, Pharm Res, vol. 10, no. 7, pp. 1046-51.

1992

Mandema, J.W., Tuk, B., van Steveninck, A.L., Breimer, D.D., Cohen, A.F., Danhof, M. , Pharmacokinetic-pharmacodynamic modeling of the central nervous system effects of midazolam and its main metabolite alpha-hydroxymidazolam in healthy volunteers, Clin Pharmacol Ther, vol. 51, no. 6, pp. 715-28.

Mandema, J.W., Kuck, M.T., Danhof, M. , In vivo modeling of the pharmacodynamic interaction between benzodiazepines which differ in intrinsic efficacy, J Pharmacol Exp Ther, vol. 261, no. 1, pp. 56-61.

Stijnen, A.M., Danhof, M., Van Bezooijen, C.F. , Increased sensitivity to the anesthetic effect of phenobarbital in aging BN/BiRij rats, J Pharmacol Exp Ther, vol. 261, no. 1, pp. 81-7.

Mandema, J.W., Heijligers-Feijen, C.D., Tukker, E., De Boer, A.G., Danhof, M. , Modeling of the effect site equilibration kinetics and pharmacodynamics of racemic baclofen and its enantiomers using quantitative EEG effect measures, J Pharmacol Exp Ther, vol. 261, no. 1, pp. 88-95.

1989

van Harten, J., van Brummelen, P., Danhof, M., Quekel, R.P., Breimer, D.D. , Pharmacokinetics and hemodynamic effects of long-term nisoldipine treatment in hypertensive patients, J Cardiovasc Pharmacol, vol. 13, no. 4, pp. 624-9.

1988

van Harten, J., van Brummelen, P., Zeegers, R.R., Danhof, M., Breimer, D.D. , The influence of infusion rate on the pharmacokinetics and haemodynamic effects of nisoldipine in man, Br J Clin Pharmacol, vol. 25, no. 6, pp. 709-17.

Dingemanse, J., Thomassen, D., Mentink, B.H., Danhof, M. , Strategy to assess the role of (inter)active metabolites in pharmacodynamic studies in-vivo: a model study with heptabarbital, J Pharm Pharmacol, vol. 40, no. 8, pp. 552-7.

1986

Kleinbloesem, C.H., van Harten, J., Wilson, J.P., Danhof, M., van Brummelen, P., Breimer, D.D. , Nifedipine: kinetics and hemodynamic effects in patients with liver cirrhosis after intravenous and oral administration, Clin Pharmacol Ther, vol. 40, no. 1, pp. 21-8.

1985

Kleinbloesem, C.H., van Brummelen, P., van Harten, J., Danhof, M., Breimer, D.D. , Nifedipine: influence of renal function on pharmacokinetic/hemodynamic relationship, Clin Pharmacol Ther, vol. 37, no. 5, pp. 563-74.

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