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Universiteit Leiden

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1992

Stijnen, A.M., Heeremans, C.E., Van Bezooijen, C.F., Niessen, W.M., Danhof, M. , Disposition of heptabarbitone in the rat: identification of a new metabolite by tandem mass spectrometry, J Pharm Pharmacol, vol. 44, no. 11, pp. 907-10.

Mandema, J.W., Kuck, M.T., Danhof, M. , Differences in intrinsic efficacy of benzodiazepines are reflected in their concentration-EEG effect relationship, Br J Pharmacol, vol. 105, no. 1, pp. 164-70.

Mandema, J.W., Heijligers-Feijen, C.D., Tukker, E., De Boer, A.G., Danhof, M. , Modeling of the effect site equilibration kinetics and pharmacodynamics of racemic baclofen and its enantiomers using quantitative EEG effect measures, J Pharmacol Exp Ther, vol. 261, no. 1, pp. 88-95.

1991

Aarons, L., Mandema, J.W., Danhof, M. , A population analysis of the pharmacokinetics and pharmacodynamics of midazolam in the rat, J Pharmacokinet Biopharm, vol. 19, no. 5, pp. 485-96.

Mandema, J.W., Veng-Pedersen, P., Danhof, M. , Estimation of amobarbital plasma-effect site equilibration kinetics. Relevance of polyexponential conductance functions, J Pharmacokinet Biopharm, vol. 19, no. 6, pp. 617-34.

Ebling, W.F., Danhof, M., Stanski, D.R. , Pharmacodynamic characterization of the electroencephalographic effects of thiopental in rats, J Pharmacokinet Biopharm, vol. 19, no. 2, pp. 123-43.

Mandema, J.W., Gubbens-Stibbe, J.M., Danhof, M. , Stability and pharmacokinetics of flumazenil in the rat, Psychopharmacology (Berl), vol. 103, no. 3, pp. 384-7.

1990

Mandema, J.W., Danhof, M. , Pharmacokinetic-pharmacodynamic modeling of the central nervous system effects of heptabarbital using aperiodic EEG analysis, J Pharmacokinet Biopharm, vol. 18, no. 5, pp. 459-81.

Dingemanse, J., Hameter, B.M., Danhof, M. , Pharmacodynamics of tolerance development to the anesthetic and anticonvulsant effects of phenobarbital in rats, J Pharm Sci, vol. 79, no. 3, pp. 207-11.

van Bree, J.B., Tio, S., de Boer, A.G., Danhof, M., Verhoef, J.C., Breimer, D.D. , Transport of desglycinamide-arginine vasopressin across the blood-brain barrier in rats as evaluated by the unit impulse response methodology, Pharm Res, vol. 7, no. 3, pp. 293-8.

Dingemanse, J., Voskuyl, R.A., Langemeijer, M.W., Postel-Westra, I, Breimer, D.D., Meinardi, H., Danhof, M. , Pharmacokinetic-pharmacodynamic modelling of the anticonvulsant effect of oxazepam in individual rats, Br J Pharmacol, vol. 99, no. 1, pp. 53-8.

1989

Dingemanse, J., van Bree, J.B., Danhof, M. , Pharmacokinetic modeling of the anticonvulsant action of phenobarbital in rats, J Pharmacol Exp Ther, vol. 249, no. 2, pp. 601-8.

Voskuyl, R.A., Dingemanse, J., Danhof, M. , Determination of the threshold for convulsions by direct cortical stimulation, Epilepsy Res, vol. 3, no. 2, pp. 120-9.

Hollander-Jansen, M., Dingemanse, J., Langemeijer, M.W., Danhof, M. , Relationship between receptor occupancy at 37 degrees C and the anticonvulsant effect of flunitrazepam in rats, Pharm Res, vol. 6, no. 7, pp. 585-91.

1988

van Bree, J.B., de Boer, A.G., Danhof, M., Verhoef, J.C., van Wimersma Greidanus, T.B., Breimer, D.D. , Radioimmunoassay of desglycinamide-arginine vasopressin and its application in a pharmacokinetic study in the rat, Peptides, vol. 9, no. 3, pp. 555-9.

Dingemanse, J., Hutson, P.H., Langemeijer, M.W., Curzon, G., Danhof, M. , Application of serial sampling of cerebrospinal fluid in pharmacodynamic studies with a drug active in the CNS: heptabarbital concentrations at onset and offset of loss of righting reflex in rats, Neuropharmacology, vol. 27, no. 5, pp. 467-74.

Dingemanse, J., Polhuijs, M., Danhof, M. , Altered pharmacokinetic-pharmacodynamic relationship of heptabarbital in experimental renal failure in rats, J Pharmacol Exp Ther, vol. 246, no. 1, pp. 371-6.

1985

Danhof, M., Hisaoka, M., Levy, G. , Kinetics of drug action in disease states. VI. Effect of experimental diabetes on phenobarbital concentrations in rats at onset of loss of righting reflex, J Pharmacol Exp Ther, vol. 232, no. 2, pp. 435-8.

1983

Vermeulen, N.P., Danhof, M., Setiawan, I, Breimer, D.D. , Disposition of hexobarbital in the rat. Estimation of "first-pass" elimination and influence of ether anesthesia, J Pharmacol Exp Ther, vol. 226, no. 1, pp. 201-5.

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