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Universiteit Leiden

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1999

Van der Graaf, P.H., Van Schaick, E.A., Visser, S.A., De Greef, H.J., Ijzerman, A.P., Danhof, M. , Mechanism-based pharmacokinetic-pharmacodynamic modeling of antilipolytic effects of adenosine A(1) receptor agonists in rats: prediction of tissue-dependent efficacy in vivo, J Pharmacol Exp Ther, vol. 290, no. 2, pp. 702-9.

1998

van Schaick, E.A., Tukker, H.E., Roelen, H.C., AP, I.J., Danhof, M. , Selectivity of action of 8-alkylamino analogues of N6-cyclopentyladenosine in vivo: haemodynamic versus anti-lipolytic responses in rats, Br J Pharmacol, vol. 124, no. 3, pp. 607-18.

1997

Van der Graaf, P.H., Danhof, M. , Analysis of drug-receptor interactions in vivo: a new approach in pharmacokinetic-pharmacodynamic modelling, Int J Clin Pharmacol Ther, vol. 35, no. 10, pp. 442-6.

Van Schaick, E.A., Math-ot, R.A., Gubbens-Stibbe, J.M., Langemeijer, M.W., Roelen, H.C., Ijzerman, A.P., Danhof, M. , 8-Alkylamino-substituted analogs of N6-cyclopentyladenosine are partial agonists for the cardiovascular adenosine A1 receptors in vivo, J Pharmacol Exp Ther, vol. 283, no. 2, pp. 800-8.

Van Der Graaf, P.H., Van Schaick, E.A., Math-ot, R.A., Ijzerman, A.P., Danhof, M. , Mechanism-based pharmacokinetic-pharmacodynamic modeling of the effects of N6-cyclopentyladenosine analogs on heart rate in rat: estimation of in vivo operational affinity and efficacy at adenosine A1 receptors, J Pharmacol Exp Ther, vol. 283, no. 2, pp. 809-16.

Bol, C., Danhof, M., Stanski, D.R., Mandema, J.W. , Pharmacokinetic-pharmacodynamic characterization of the cardiovascular, hypnotic, EEG and ventilatory responses to dexmedetomidine in the rat, J Pharmacol Exp Ther, vol. 283, no. 3, pp. 1051-8.

van Schaick, E.A., Kulkarni, C., von Frijtag Drabbe Kunzel, J.K., Mathot, R.A., Cristalli, G., AP, I.J., Danhof, M. , Time course of action of three adenosine A1 receptor agonists with differing lipophilicity in rats: comparison of pharmacokinetic, haemodynamic and EEG effects, Naunyn Schmiedebergs Arch Pharmacol, vol. 356, no. 6, pp. 827-37.

1996

Van Schaick, E.A., Jacobson, K.A., Kim, H.O., AP, I.J., Danhof, M. , Hemodynamic effects and histamine release elicited by the selective adenosine A3 receptor agonist 2-Cl-IB-MECA in conscious rats, Eur J Pharmacol, vol. 308, no. 3, pp. 311-4.

Mathot, R.A., Wenden, E.M., Soudijn, W., Breimer, D.D., Ijzerman, A.P., Danhof, M. , Partial agonism of the nonselective adenosine receptor agonist 8-butylaminoadenosine at the A1 receptor in vivo, J Pharmacol Exp Ther, vol. 279, no. 3, pp. 1439-46.

1995

van der Wenden, E.M., von Frijtag Drabbe Kunzel, J.K., Mathot, R.A., Danhof, M., AP, I.J., Soudijn, W. , Ribose-modified adenosine analogues as potential partial agonists for the adenosine receptor, J Med Chem, vol. 38, no. 20, pp. 4000-6.

Mathot, R.A., Van der Wenden, E.M., Soudijn, W., AP, I.J., Danhof, M. , Deoxyribose analogues of N6-cyclopentyladenosine (CPA): partial agonists at the adenosine A1 receptor in vivo, Br J Pharmacol, vol. 116, no. 3, pp. 1957-64.

Van der Wenden, E.M., Hartog-Witte, H.R., Roelen, H.C., von Frijtag Drabbe Kunzel, J.K., Pirovano, I.M., Mathot, R.A., Danhof, M., Van Aerschot, A., Lidaks, M.J., AP, I.J., , . et al., 8-substituted adenosine and theophylline-7-riboside analogues as potential partial agonists for the adenosine A1 receptor, Eur J Pharmacol, vol. 290, no. 3, pp. 189-99.

Appel, S., Mathot, R.A., Langemeijer, M.W., AP, I.J., Danhof, M. , Modelling of the pharmacodynamic interaction of an A1 adenosine receptor agonist and antagonist in vivo: N6-cyclopentyladenosine and 8-cyclopentyltheophylline, Br J Pharmacol, vol. 115, no. 7, pp. 1253-9.

Mathot, R.A., Van den Aarsen, B.C., Soudijn, W., Breimer, D.D., Ijzerman, A.P., Danhof, M. , Pharmacokinetic-pharmacodynamic modelling of the cardiovascular effects of R- and S-N6-phenylisopropyladenosine in conscious normotensive rats, J Pharmacol Exp Ther, vol. 273, no. 1, pp. 405-14.

1994

Mathot, R.A., van Schaick, E.A., Langemeijer, M.W., Soudijn, W., Breimer, D.D., Ijzerman, A.P., Danhof, M. , Pharmacokinetic-pharmacodynamic relationship of the cardiovascular effects of adenosine A1 receptor agonist N6-cyclopentyladenosine in the rat, J Pharmacol Exp Ther, vol. 268, no. 2, pp. 616-24.

1993

Van Steveninck, A.L., Mandema, J.W., Tuk, B., Van Dijk, J.G., Schoemaker, H.C., Danhof, M., Cohen, A.F. , A comparison of the concentration-effect relationships of midazolam for EEG-derived parameters and saccadic peak velocity, Br J Clin Pharmacol, vol. 36, no. 2, pp. 109-15.

1992

Soons, P.A., van den Berg, G., Danhof, M., van Brummelen, P., Jansen, J.B., Lamers, C.B., Breimer, D.D. , Influence of single- and multiple-dose omeprazole treatment on nifedipine pharmacokinetics and effects in healthy subjects, Eur J Clin Pharmacol, vol. 42, no. 3, pp. 319-24.

1988

van Harten, J., van Brummelen, P., Lodewijks, M.T., Danhof, M., Breimer, D.D. , Pharmacokinetics and hemodynamic effects of nisoldipine and its interaction with cimetidine, Clin Pharmacol Ther, vol. 43, no. 3, pp. 332-41.

1987

Kleinbloesem, C.H., van Brummelen, P., Danhof, M., Faber, H., Urquhart, J., Breimer, D.D. , Rate of increase in the plasma concentration of nifedipine as a major determinant of its hemodynamic effects in humans, Clin Pharmacol Ther, vol. 41, no. 1, pp. 26-30.

1986

Kleinbloesem, C.H., van Harten, J., Wilson, J.P., Danhof, M., van Brummelen, P., Breimer, D.D. , Nifedipine: kinetics and hemodynamic effects in patients with liver cirrhosis after intravenous and oral administration, Clin Pharmacol Ther, vol. 40, no. 1, pp. 21-8.

1985

Kleinbloesem, C.H., van Brummelen, P., van Harten, J., Danhof, M., Breimer, D.D. , Nifedipine: influence of renal function on pharmacokinetic/hemodynamic relationship, Clin Pharmacol Ther, vol. 37, no. 5, pp. 563-74.

1984

Kleinbloesem, C.H., van Brummelen, P., Faber, H., Danhof, M., Vermeulen, N.P., Breimer, D.D. , Variability in nifedipine pharmacokinetics and dynamics: a new oxidation polymorphism in man, Biochem Pharmacol, vol. 33, no. 22, pp. 3721-4.

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