LACDR

Universiteit Leiden

List
Filter

Found 23 results. Export: Tagged | XML

Filters: keyword is Half-Life [Clear All Filters]

2007

Muller, A.E., DeJongh, J., Bult, Y., Goessens, W.H., Mouton, J.W., Danhof, M., van den Anker, J.N. , Pharmacokinetics of penicillin G in infants with a gestational age of less than 32 weeks, Antimicrob Agents Chemother, vol. 51, no. 10, pp. 3720-5.

Yassen, A., Olofsen, E., Romberg, R., Sarton, E., Teppema, L., Danhof, M., Dahan, A. , Mechanism-based PK/PD modeling of the respiratory depressant effect of buprenorphine and fentanyl in healthy volunteers, Clin Pharmacol Ther, vol. 81, no. 1, pp. 50-8.

Yassen, A., Olofsen, E., van Dorp, E., Sarton, E., Teppema, L., Danhof, M., Dahan, A. , Mechanism-based pharmacokinetic-pharmacodynamic modelling of the reversal of buprenorphine-induced respiratory depression by naloxone : a study in healthy volunteers, Clin Pharmacokinet, vol. 46, no. 11, pp. 965-80.

2002

Visser, S.A., Gladdines, W.W., van der Graaf, P.H., Peletier, L.A., Danhof, M. , Neuroactive steroids differ in potency but not in intrinsic efficacy at the GABA(A) receptor in vivo, J Pharmacol Exp Ther, vol. 303, no. 2, pp. 616-26.

1998

van der Geest, R., van Laar, T., Kruger, P.P., Gubbens-Stibbe, J.M., Bodde, H.E., Roos, R.A., Danhof, M. , Pharmacokinetics, enantiomer interconversion, and metabolism of R-apomorphine in patients with idiopathic Parkinson's disease, Clin Neuropharmacol, vol. 21, no. 3, pp. 159-68.

van Schaick, E.A., Tukker, H.E., Roelen, H.C., AP, I.J., Danhof, M. , Selectivity of action of 8-alkylamino analogues of N6-cyclopentyladenosine in vivo: haemodynamic versus anti-lipolytic responses in rats, Br J Pharmacol, vol. 124, no. 3, pp. 607-18.

Cox, E.H., Kuipers, J.A., Danhof, M. , Pharmacokinetic-pharmacodynamic modelling of the EEG effect of alfentanil in rats: assessment of rapid functional adaptation, Br J Pharmacol, vol. 124, no. 7, pp. 1534-40.

1997

Tuk, B., Danhof, M., Mandema, J.W. , The impact of arteriovenous concentration differences on pharmacodynamic parameter estimates, J Pharmacokinet Biopharm, vol. 25, no. 1, pp. 39-62.

van Schaick, E.A., Kulkarni, C., von Frijtag Drabbe Kunzel, J.K., Mathot, R.A., Cristalli, G., AP, I.J., Danhof, M. , Time course of action of three adenosine A1 receptor agonists with differing lipophilicity in rats: comparison of pharmacokinetic, haemodynamic and EEG effects, Naunyn Schmiedebergs Arch Pharmacol, vol. 356, no. 6, pp. 827-37.

1993

Van Steveninck, A.L., Mandema, J.W., Tuk, B., Van Dijk, J.G., Schoemaker, H.C., Danhof, M., Cohen, A.F. , A comparison of the concentration-effect relationships of midazolam for EEG-derived parameters and saccadic peak velocity, Br J Clin Pharmacol, vol. 36, no. 2, pp. 109-15.

1992

Stijnen, A.M., Danhof, M., van Bezooijen, C.F. , Age and the pharmacokinetic-pharmacodynamic relationship of phenobarbital in rats: "pseudo"-longitudinal vs cross-sectional study design, Pharm Res, vol. 9, no. 11, pp. 1456-9.

1991

Mandema, J.W., Gubbens-Stibbe, J.M., Danhof, M. , Stability and pharmacokinetics of flumazenil in the rat, Psychopharmacology (Berl), vol. 103, no. 3, pp. 384-7.

1988

Dingemanse, J., Hutson, P.H., Langemeijer, M.W., Curzon, G., Danhof, M. , Application of serial sampling of cerebrospinal fluid in pharmacodynamic studies with a drug active in the CNS: heptabarbital concentrations at onset and offset of loss of righting reflex in rats, Neuropharmacology, vol. 27, no. 5, pp. 467-74.

van Harten, J., van Brummelen, P., Lodewijks, M.T., Danhof, M., Breimer, D.D. , Pharmacokinetics and hemodynamic effects of nisoldipine and its interaction with cimetidine, Clin Pharmacol Ther, vol. 43, no. 3, pp. 332-41.

1987

Posner, J., Danhof, M., Teunissen, M.W., Breimer, D.D., Whiteman, P.D. , The disposition of antipyrine and its metabolites in young and elderly healthy volunteers, Br J Clin Pharmacol, vol. 24, no. 1, pp. 51-5.

1986

Kleinbloesem, C.H., van Harten, J., Wilson, J.P., Danhof, M., van Brummelen, P., Breimer, D.D. , Nifedipine: kinetics and hemodynamic effects in patients with liver cirrhosis after intravenous and oral administration, Clin Pharmacol Ther, vol. 40, no. 1, pp. 21-8.

1985

Kleinbloesem, C.H., van Brummelen, P., van Harten, J., Danhof, M., Breimer, D.D. , Nifedipine: influence of renal function on pharmacokinetic/hemodynamic relationship, Clin Pharmacol Ther, vol. 37, no. 5, pp. 563-74.

1983

Vermeulen, N.P., Danhof, M., Setiawan, I, Breimer, D.D. , Disposition of hexobarbital in the rat. Estimation of "first-pass" elimination and influence of ether anesthesia, J Pharmacol Exp Ther, vol. 226, no. 1, pp. 201-5.

1982

Danhof, M., Verbeek, R.M., van Boxtel, C.J., Boeijinga, J.K., Breimer, D.D. , Differential effects of enzyme induction on antipyrine metabolite formation, Br J Clin Pharmacol, vol. 13, no. 3, pp. 379-86.

1981

Danhof, M., Idle, J.R., Teunissen, M.W., Sloan, T.P., Breimer, D.D., Smith, R.L. , Influence of the genetically controlled deficiency in debrisoquine hydroxylation on antipyrine metabolite formation, Pharmacology, vol. 22, no. 6, pp. 349-58.

1979

Danhof, M., Krom, D.P., Breimer, D.D. , Studies on the different metabolic pathways of antipyrine in rats: influence of phenobarbital and 3-methylcholanthrene treatment, Xenobiotica, vol. 9, no. 11, pp. 695-702.

Danhof, M., Breimer, D.D. , Studies on the different metabolic pathways of antipyrine in man. I. Oral administration of 250, 500 and 1000 mg to healthy volunteers, Br J Clin Pharmacol, vol. 8, no. 6, pp. 529-37.

Danhof, M., der Groot-van Vis, E., Breiner, D.D. , Assay of antipyrine and its primary metabolites in plasma, saliva and urine by high-performance liquid chromatography and some preliminary results in man, Pharmacology, vol. 18, no. 4, pp. 210-23.

LACDR