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- 2009
Changes in GABAA receptor properties in amygdala kindled animals: in vivo studies using [11C]flumazenil and positron emission tomography,
Epilepsia, vol. 50, no. 1, pp. 88-98.
Pharmacokinetic-pharmacodynamic model for the reversal of neuromuscular blockade by sugammadex,
Anesthesiology, vol. 110, no. 1, pp. 95-105.
- 2008
Sensitivity of the individual items of the Hamilton depression rating scale to response and its consequences for the assessment of efficacy,
J Psychiatr Res, vol. 42, no. 12, pp. 1000-9.
- 2007
Population pharmacokinetic modelling of non-linear brain distribution of morphine: influence of active saturable influx and P-glycoprotein mediated efflux,
Br J Pharmacol, vol. 151, no. 5, pp. 701-12.
Application of the convection-dispersion equation to modelling oral drug absorption,
Bull Math Biol, vol. 69, no. 1, pp. 181-95.
- 2005
Population pharmacokinetic analysis for simultaneous determination of B (max) and K (D) in vivo by positron emission tomography,
Mol Imaging Biol, vol. 7, no. 6, pp. 411-21.
- 2003
Dose-dependent EEG effects of zolpidem provide evidence for GABA(A) receptor subtype selectivity in vivo,
J Pharmacol Exp Ther, vol. 304, no. 3, pp. 1251-7.
Pharmacodynamic analysis of the interaction between tiagabine and midazolam with an allosteric model that incorporates signal transduction,
Epilepsia, vol. 44, no. 3, pp. 329-38.
Mechanism-based pharmacokinetic/pharmacodynamic modeling of the electroencephalogram effects of GABAA receptor modulators: in vitro-in vivo correlations,
J Pharmacol Exp Ther, vol. 304, no. 1, pp. 88-101.
- 2002
Therapeutic efficacy of the adenosine A1 receptor agonist N6-cyclopentyladenosine (CPA) against organophosphate intoxication,
Arch Toxicol, vol. 76, no. 11, pp. 650-6.
Electroencephalography parameters as biomarkers: extrapolation from laboratory animals to humans,
Methods Find Exp Clin Pharmacol, vol. 24 Suppl D, pp. 63-4.
- 2000
Mechanism-based modeling of functional adaptation upon chronic treatment with midazolam,
Pharm Res, vol. 17, no. 3, pp. 321-7.
- 1999
Stereoselective central nervous system effects of the R- and S-isomers of the GABA uptake blocker N-(4, 4-di-(3-methylthien-2-yl)but-3-enyl) nipecotic acid in the rat,
Br J Pharmacol, vol. 128, no. 8, pp. 1651-8.
Mechanism-based pharmacokinetic-pharmacodynamic modeling of antilipolytic effects of adenosine A(1) receptor agonists in rats: prediction of tissue-dependent efficacy in vivo,
J Pharmacol Exp Ther, vol. 290, no. 2, pp. 702-9.
- 1997
Analysis of drug-receptor interactions in vivo: a new approach in pharmacokinetic-pharmacodynamic modelling,
Int J Clin Pharmacol Ther, vol. 35, no. 10, pp. 442-6.
Pharmacokinetic-pharmacodynamic modelling of the EEG effect of alfentanil in rats,
J Pharmacol Toxicol Methods, vol. 38, no. 2, pp. 99-108.
- 1996
Pharmacokinetic/pharmacodynamic relationship of benzodiazepines in the direct cortical stimulation model of anticonvulsant effect,
J Pharmacol Exp Ther, vol. 279, no. 2, pp. 803-12.
- 1993
Increased sensitivity to the anticonvulsant effect of valproate in aging BN/BiRij rats,
Pharm Res, vol. 10, no. 7, pp. 1046-51.
- 1992
Pharmacodynamics of the anticonvulsant effect of oxazepam in aging BN/BiRij rats,
Br J Pharmacol, vol. 107, no. 1, pp. 165-70.
Differences in intrinsic efficacy of benzodiazepines are reflected in their concentration-EEG effect relationship,
Br J Pharmacol, vol. 105, no. 1, pp. 164-70.
Influence of single- and multiple-dose omeprazole treatment on nifedipine pharmacokinetics and effects in healthy subjects,
Eur J Clin Pharmacol, vol. 42, no. 3, pp. 319-24.
- 1991
The influence of dosage time of midazolam on its pharmacokinetics and effects in humans,
Clin Pharmacol Ther, vol. 50, no. 1, pp. 16-24.
Liquid chromatography-thermospray tandem mass spectrometry for identification of a heptabarbital metabolite and sample work-up artefacts,
J Chromatogr, vol. 554, no. 1-2, pp. 205-14.



