LACDR

Universiteit Leiden

List
Filter

Found 28 results. Export: Tagged | XML

Filters: keyword is GA [Clear All Filters]

2009

Liefaard, L.C., Ploeger, B.A., Molthoff, C.F., de Jong, H.W., Dijkstra, J., van der Weerd, L., Lammertsma, A.A., Danhof, M., Voskuyl, R.A. , Changes in GABAA receptor properties in amygdala kindled animals: in vivo studies using [11C]flumazenil and positron emission tomography, Epilepsia, vol. 50, no. 1, pp. 88-98.

Ploeger, B.A., Smeets, J., Strougo, A., Drenth, H.J., Ruigt, G., Houwing, N., Danhof, M. , Pharmacokinetic-pharmacodynamic model for the reversal of neuromuscular blockade by sugammadex, Anesthesiology, vol. 110, no. 1, pp. 95-105.

2008

Santen, G., Gomeni, R., Danhof, M., Della Pasqua, O. , Sensitivity of the individual items of the Hamilton depression rating scale to response and its consequences for the assessment of efficacy, J Psychiatr Res, vol. 42, no. 12, pp. 1000-9.

2007

Groenendaal, D., Freijer, J., de Mik, D., Bouw, M.R., Danhof, M., de Lange, E.C. , Population pharmacokinetic modelling of non-linear brain distribution of morphine: influence of active saturable influx and P-glycoprotein mediated efflux, Br J Pharmacol, vol. 151, no. 5, pp. 701-12.

Freijer, J. I, Post, T.M., Ploeger, B.A., DeJongh, J., Danhof, M. , Application of the convection-dispersion equation to modelling oral drug absorption, Bull Math Biol, vol. 69, no. 1, pp. 181-95.

2005

Liefaard, L.C., Ploeger, B.A., Molthoff, C.F., Boellaard, R., Lammertsma, A.A., Danhof, M., Voskuyl, R.A. , Population pharmacokinetic analysis for simultaneous determination of B (max) and K (D) in vivo by positron emission tomography, Mol Imaging Biol, vol. 7, no. 6, pp. 411-21.

2003

Visser, S.A., Wolters, F.L., van der Graaf, P.H., Peletier, L.A., Danhof, M. , Dose-dependent EEG effects of zolpidem provide evidence for GABA(A) receptor subtype selectivity in vivo, J Pharmacol Exp Ther, vol. 304, no. 3, pp. 1251-7.

Jonker, D.M., Vermeij, D.A., Edelbroek, P.M., Voskuyl, R.A., Piotrovsky, V.K., Danhof, M. , Pharmacodynamic analysis of the interaction between tiagabine and midazolam with an allosteric model that incorporates signal transduction, Epilepsia, vol. 44, no. 3, pp. 329-38.

Visser, S.A., Wolters, F.L., Gubbens-Stibbe, J.M., Tukker, E., Van Der Graaf, P.H., Peletier, L.A., Danhof, M. , Mechanism-based pharmacokinetic/pharmacodynamic modeling of the electroencephalogram effects of GABAA receptor modulators: in vitro-in vivo correlations, J Pharmacol Exp Ther, vol. 304, no. 1, pp. 88-101.

2002

Bueters, T.J., Groen, B., Danhof, M., AP, I.J., Van Helden, H.P. , Therapeutic efficacy of the adenosine A1 receptor agonist N6-cyclopentyladenosine (CPA) against organophosphate intoxication, Arch Toxicol, vol. 76, no. 11, pp. 650-6.

Danhof, M. , Electroencephalography parameters as biomarkers: extrapolation from laboratory animals to humans, Methods Find Exp Clin Pharmacol, vol. 24 Suppl D, pp. 63-4.

2000

Cleton, A., Odman, J., Van der Graaf, P.H., Ghijsen, W., Voskuyl, R., Danhof, M. , Mechanism-based modeling of functional adaptation upon chronic treatment with midazolam, Pharm Res, vol. 17, no. 3, pp. 321-7.

Garrido, M., Gubbens-Stibbe, J., Tukker, E., Cox, E., von Frijtag, J., Kunzel, D., A, I.J., Danhof, M., van der Graaf, P.H. , Pharmacokinetic-pharmacodynamic analysis of the EEG effect of alfentanil in rats following beta-funaltrexamine-induced mu-opioid receptor "knockdown" in vivo, Pharm Res, vol. 17, no. 6, pp. 653-9.

1999

Cleton, A., de Greef, H.J., Edelbroek, P.M., Voskuyl, R.A., Danhof, M. , Stereoselective central nervous system effects of the R- and S-isomers of the GABA uptake blocker N-(4, 4-di-(3-methylthien-2-yl)but-3-enyl) nipecotic acid in the rat, Br J Pharmacol, vol. 128, no. 8, pp. 1651-8.

Van der Graaf, P.H., Van Schaick, E.A., Visser, S.A., De Greef, H.J., Ijzerman, A.P., Danhof, M. , Mechanism-based pharmacokinetic-pharmacodynamic modeling of antilipolytic effects of adenosine A(1) receptor agonists in rats: prediction of tissue-dependent efficacy in vivo, J Pharmacol Exp Ther, vol. 290, no. 2, pp. 702-9.

1997

Van der Graaf, P.H., Danhof, M. , Analysis of drug-receptor interactions in vivo: a new approach in pharmacokinetic-pharmacodynamic modelling, Int J Clin Pharmacol Ther, vol. 35, no. 10, pp. 442-6.

Cox, E.H., Van Hemert, J.G., Tukker, E.J., Danhof, M. , Pharmacokinetic-pharmacodynamic modelling of the EEG effect of alfentanil in rats, J Pharmacol Toxicol Methods, vol. 38, no. 2, pp. 99-108.

1996

Hoogerkamp, A., Arends, R.H., Bomers, A.M., Mandema, J.W., Voskuyl, R.A., Danhof, M. , Pharmacokinetic/pharmacodynamic relationship of benzodiazepines in the direct cortical stimulation model of anticonvulsant effect, J Pharmacol Exp Ther, vol. 279, no. 2, pp. 803-12.

1993

Mathot, R.A., Appel, S., van Schaick, E.A., Soudijn, W., AP, I.J., Danhof, M. , High-performance liquid chromatography of the adenosine A1 agonist N6-cyclopentyladenosine and the A1 antagonist 8-cyclopentyltheophylline and its application in a pharmacokinetic study in rats, J Chromatogr, vol. 620, no. 1, pp. 113-20.

Stijnen, A.M., Hovinga, S., Langemeijer, M.W., Hoogerkamp, A., van Bezooijen, C.F., Danhof, M. , Increased sensitivity to the anticonvulsant effect of valproate in aging BN/BiRij rats, Pharm Res, vol. 10, no. 7, pp. 1046-51.

1992

Stijnen, A.M., Postel-Westra, I, Langemeijer, M.W., Hoogerkamp, A., Voskuyl, R.A., van Bezooijen, C.F., Danhof, M. , Pharmacodynamics of the anticonvulsant effect of oxazepam in aging BN/BiRij rats, Br J Pharmacol, vol. 107, no. 1, pp. 165-70.

Mandema, J.W., Kuck, M.T., Danhof, M. , Differences in intrinsic efficacy of benzodiazepines are reflected in their concentration-EEG effect relationship, Br J Pharmacol, vol. 105, no. 1, pp. 164-70.

Soons, P.A., van den Berg, G., Danhof, M., van Brummelen, P., Jansen, J.B., Lamers, C.B., Breimer, D.D. , Influence of single- and multiple-dose omeprazole treatment on nifedipine pharmacokinetics and effects in healthy subjects, Eur J Clin Pharmacol, vol. 42, no. 3, pp. 319-24.

1991

Koopmans, R., Dingemanse, J., Danhof, M., Horsten, G.P., van Boxtel, C.J. , The influence of dosage time of midazolam on its pharmacokinetics and effects in humans, Clin Pharmacol Ther, vol. 50, no. 1, pp. 16-24.

Heeremans, C.E., Stijnen, A.M., van der Hoeven, R.A., Niessen, W.M., Danhof, M., van der Greef, J. , Liquid chromatography-thermospray tandem mass spectrometry for identification of a heptabarbital metabolite and sample work-up artefacts, J Chromatogr, vol. 554, no. 1-2, pp. 205-14.

LACDR