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Universiteit Leiden

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2009

Ploeger, B.A., Smeets, J., Strougo, A., Drenth, H.J., Ruigt, G., Houwing, N., Danhof, M. , Pharmacokinetic-pharmacodynamic model for the reversal of neuromuscular blockade by sugammadex, Anesthesiology, vol. 110, no. 1, pp. 95-105.

2007

Jonker, D.M., Voskuyl, R.A., Danhof, M. , Synergistic combinations of anticonvulsant agents: what is the evidence from animal experiments?, Epilepsia, vol. 48, no. 3, pp. 412-34.

Yassen, A., Olofsen, E., van Dorp, E., Sarton, E., Teppema, L., Danhof, M., Dahan, A. , Mechanism-based pharmacokinetic-pharmacodynamic modelling of the reversal of buprenorphine-induced respiratory depression by naloxone : a study in healthy volunteers, Clin Pharmacokinet, vol. 46, no. 11, pp. 965-80.

2005

Jonker, D.M., Visser, S.A., van der Graaf, P.H., Voskuyl, R.A., Danhof, M. , Towards a mechanism-based analysis of pharmacodynamic drug-drug interactions in vivo, Pharmacol Ther, vol. 106, no. 1, pp. 1-18.

2004

Jonker, D.M., Voskuyl, R.A., Danhof, M. , Pharmacodynamic analysis of the anticonvulsant effects of tiagabine and lamotrigine in combination in the rat, Epilepsia, vol. 45, no. 5, pp. 424-35.

2003

Visser, S.A., Huntjens, D.R., van der Graaf, P.H., Peletier, L.A., Danhof, M. , Mechanism-based modeling of the pharmacodynamic interaction of alphaxalone and midazolam in rats, J Pharmacol Exp Ther, vol. 307, no. 2, pp. 765-75.

Bueters, T.J., Joosen, M.J., van Helden, H.P., Ijzerman, A.P., Danhof, M. , Adenosine A1 receptor agonist N6-cyclopentyladenosine affects the inactivation of acetylcholinesterase in blood and brain by sarin, J Pharmacol Exp Ther, vol. 304, no. 3, pp. 1307-13.

2002

Visser, S.A., Gladdines, W.W., van der Graaf, P.H., Peletier, L.A., Danhof, M. , Neuroactive steroids differ in potency but not in intrinsic efficacy at the GABA(A) receptor in vivo, J Pharmacol Exp Ther, vol. 303, no. 2, pp. 616-26.

Tuk, B., van Gool, T., Danhof, M. , Mechanism-based pharmacodynamic modeling of the interaction of midazolam, bretazenil, and zolpidem with ethanol, J Pharmacokinet Pharmacodyn, vol. 29, no. 3, pp. 235-50.

Swart, E.L., van der Hoven, B., Groeneveld, A.B., Touw, D.J., Danhof, M. , Correlation between midazolam and lignocaine pharmacokinetics and MEGX formation in healthy volunteers, Br J Clin Pharmacol, vol. 53, no. 2, pp. 133-9.

1999

Tuk, B., van Oostenbruggen, M.F., Herben, V.M., Mandema, J.W., Danhof, M. , Characterization of the pharmacodynamic interaction between parent drug and active metabolite in vivo: midazolam and alpha-OH-midazolam, J Pharmacol Exp Ther, vol. 289, no. 2, pp. 1067-74.

Cox, E.H., Langemeijer, M.W., Gubbens-Stibbe, J.M., Muir, K.T., Danhof, M. , The comparative pharmacodynamics of remifentanil and its metabolite, GR90291, in a rat electroencephalographic model, Anesthesiology, vol. 90, no. 2, pp. 535-44.

1998

Della Paschoa, O.E., Kruk, M.R., Hamstra, R., Voskuyl, R.A., Danhof, M. , Pharmacodynamic interaction between phenytoin and sodium valproate changes seizure thresholds and pattern, Br J Pharmacol, vol. 125, no. 5, pp. 997-1004.

Della Paschoa, O.E., Voskuyl, R.A., Danhof, M. , Modelling of the pharmacodynamic interaction between phenytoin and sodium valproate, Br J Pharmacol, vol. 125, no. 7, pp. 1610-6.

1995

Hoyo-Vadillo, C., Mandema, J.W., Danhof, M. , Pharmacodynamic interaction between midazolam and a low dose of ethanol in vivo, Life Sci, vol. 57, no. 4, pp. 325-33.

1992

Danhof, M., Mandema, J.W. , Modelling of the pharmacodynamics and pharmacodynamic interactions of CNS active drugs, Int J Clin Pharmacol Ther Toxicol, vol. 30, no. 11, pp. 516-9.

Mandema, J.W., Tuk, B., van Steveninck, A.L., Breimer, D.D., Cohen, A.F., Danhof, M. , Pharmacokinetic-pharmacodynamic modeling of the central nervous system effects of midazolam and its main metabolite alpha-hydroxymidazolam in healthy volunteers, Clin Pharmacol Ther, vol. 51, no. 6, pp. 715-28.

Mandema, J.W., Tukker, E., Danhof, M. , In vivo characterization of the pharmacodynamic interaction of a benzodiazepine agonist and antagonist: midazolam and flumazenil, J Pharmacol Exp Ther, vol. 260, no. 1, pp. 36-44.

Mandema, J.W., Kuck, M.T., Danhof, M. , In vivo modeling of the pharmacodynamic interaction between benzodiazepines which differ in intrinsic efficacy, J Pharmacol Exp Ther, vol. 261, no. 1, pp. 56-61.

Soons, P.A., van den Berg, G., Danhof, M., van Brummelen, P., Jansen, J.B., Lamers, C.B., Breimer, D.D. , Influence of single- and multiple-dose omeprazole treatment on nifedipine pharmacokinetics and effects in healthy subjects, Eur J Clin Pharmacol, vol. 42, no. 3, pp. 319-24.

Danhof, M., de Boer, A., Magnani, H.N., Stiekema, J.C. , Pharmacokinetic considerations on Orgaran (Org 10172) therapy, Haemostasis, vol. 22, no. 2, pp. 73-84.

1991

de Boer, A., Stiekema, J.C., Danhof, M., van Dinther, T.G., Boeijinga, J.K., Cohen, A.F., Breimer, D.D. , Studies of interaction of a low-molecular-weight heparinoid (Org 10172) with cloxacillin and ticarcillin in healthy male volunteers, Antimicrob Agents Chemother, vol. 35, no. 10, pp. 2110-5.

Breimer, L.T., Burm, A.G., Danhof, M., Hennis, P.J., Vletter, A.A., de Voogt, J.W., Spierdijk, J., Bovill, J.G. , Pharmacokinetic-pharmacodynamic modelling of the interaction between flumazenil and midazolam in volunteers by aperiodic EEG analysis, Clin Pharmacokinet, vol. 20, no. 6, pp. 497-508.

de Boer, A., Stiekema, J.C., Danhof, M., Breimer, D.D. , Influence of chlorthalidone on the pharmacokinetics and pharmacodynamics of Org 10172 (Lomoparan), a low molecular weight heparinoid, in healthy volunteers, J Clin Pharmacol, vol. 31, no. 7, pp. 611-7.

De Boer, A., Stiekema, J.C., Danhof, M., Breimer, D.D. , The influence of Org 10172, a low molecular weight heparinoid, on antipyrine metabolism and the effect of enzyme induction on the response to Org 10172, Br J Clin Pharmacol, vol. 32, no. 1, pp. 23-9.

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