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Universiteit Leiden

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2008

Ravenstijn, P.G., Merlini, M., Hameetman, M., Murray, T.K., Ward, M.A., Lewis, H., Ball, G., Mottart, C., de Ville Goyet, C., Lemarchand, T., van Belle, K., O'Neill, M.J., Danhof, M., de Lange, E.C. , The exploration of rotenone as a toxin for inducing Parkinson's disease in rats, for application in BBB transport and PK-PD experiments, J Pharmacol Toxicol Methods, vol. 57, no. 2, pp. 114-30.

Geldof, M., Freijer, J., van Beijsterveldt, L., Danhof, M. , Pharmacokinetic modeling of non-linear brain distribution of fluvoxamine in the rat, Pharm Res, vol. 25, no. 4, pp. 792-804.

2007

Groenendaal, D., Freijer, J., de Mik, D., Bouw, M.R., Danhof, M., de Lange, E.C. , Population pharmacokinetic modelling of non-linear brain distribution of morphine: influence of active saturable influx and P-glycoprotein mediated efflux, Br J Pharmacol, vol. 151, no. 5, pp. 701-12.

2005

Liefaard, L.C., Ploeger, B.A., Molthoff, C.F., Boellaard, R., Lammertsma, A.A., Danhof, M., Voskuyl, R.A. , Population pharmacokinetic analysis for simultaneous determination of B (max) and K (D) in vivo by positron emission tomography, Mol Imaging Biol, vol. 7, no. 6, pp. 411-21.

Visser, C.C., Stevanovic, S., Voorwinden, L.H., van Bloois, L., Gaillard, P.J., Danhof, M., Crommelin, D.J., de Boer, A.G. , Targeting liposomes with protein drugs to the blood-brain barrier in vitro, Eur J Pharm Sci, vol. 25, no. 2-3, pp. 299-305.

Schaddelee, M.P., Read, K.D., Cleypool, C.G., Ijzerman, A.P., Danhof, M., de Boer, A.G. , Brain penetration of synthetic adenosine A1 receptor agonists in situ: role of the rENT1 nucleoside transporter and binding to blood constituents, Eur J Pharm Sci, vol. 24, no. 1, pp. 59-66.

2004

Schaddelee, M.P., Groenendaal, D., DeJongh, J., Cleypool, C.G., AP, I.J., De Boer, A.G., Danhof, M. , Population pharmacokinetic modeling of blood-brain barrier transport of synthetic adenosine A1 receptor agonists, J Pharmacol Exp Ther, vol. 311, no. 3, pp. 1138-46.

Visser, C.C., Stevanovic, S., Heleen Voorwinden, L., Gaillard, P.J., Crommelin, D.J., Danhof, M., De Boer, A.G. , Validation of the transferrin receptor for drug targeting to brain capillary endothelial cells in vitro, J Drug Target, vol. 12, no. 3, pp. 145-50.

2003

Bueters, T.J., AP, I.J., van Helden, H.P., Danhof, M. , Characterization of the pharmacokinetics, brain distribution, and therapeutic efficacy of the adenosine A1 receptor partial agonist 2'-deoxy-N6-cyclopentyladenosine in sarin-poisoned rats, Toxicol Appl Pharmacol, vol. 192, no. 1, pp. 86-94.

Schaddelee, M.P., Voorwinden, H.L., Groenendaal, D., Hersey, A., Ijzerman, A.P., Danhof, M., De Boer, A.G. , Blood-brain barrier transport of synthetic adenosine A1 receptor agonists in vitro: structure transport relationships, Eur J Pharm Sci, vol. 20, no. 3, pp. 347-56.

Schaddelee, M.P., Voorwinden, H.L., van Tilburg, E.W., Pateman, T.J., Ijzerman, A.P., Danhof, M., de Boer, A.G. , Functional role of adenosine receptor subtypes in the regulation of blood-brain barrier permeability: possible implications for the design of synthetic adenosine derivatives, Eur J Pharm Sci, vol. 19, no. 1, pp. 13-22.

Bueters, T.J., Joosen, M.J., van Helden, H.P., Ijzerman, A.P., Danhof, M. , Adenosine A1 receptor agonist N6-cyclopentyladenosine affects the inactivation of acetylcholinesterase in blood and brain by sarin, J Pharmacol Exp Ther, vol. 304, no. 3, pp. 1307-13.

2002

de Lange, E.C., Danhof, M. , Considerations in the use of cerebrospinal fluid pharmacokinetics to predict brain target concentrations in the clinical setting: implications of the barriers between blood and brain, Clin Pharmacokinet, vol. 41, no. 10, pp. 691-703.

2000

Cleton, A., Odman, J., Van der Graaf, P.H., Ghijsen, W., Voskuyl, R., Danhof, M. , Mechanism-based modeling of functional adaptation upon chronic treatment with midazolam, Pharm Res, vol. 17, no. 3, pp. 321-7.

Cleton, A., Altorf, B.A., Voskuyl, R.A., Danhof, M. , Effect of amygdala kindling on the central nervous system effects of tiagabine: EEG effects versus brain GABA levels, Br J Pharmacol, vol. 130, no. 5, pp. 1037-44.

Cleton, A., Altorf, B.A., Voskuyl, R.A., Danhof, M. , Pharmacokinetic-pharmacodynamic modelling of tiagabine CNS effects upon chronic treatment in rats: lack of change in concentration-EEG effect relationship, Eur J Pharm Sci, vol. 12, no. 2, pp. 141-50.

1999

Cleton, A., Van der Graaf, P.H., Ghijsen, W., Voskuyl, R., Danhof, M. , Mechanism-based modeling of adaptive changes in the pharmacodynamics of midazolam in the kindling model of epilepsy, Pharm Res, vol. 16, no. 11, pp. 1702-9.

Cox, E.H., Langemeijer, M.W., Gubbens-Stibbe, J.M., Muir, K.T., Danhof, M. , The comparative pharmacodynamics of remifentanil and its metabolite, GR90291, in a rat electroencephalographic model, Anesthesiology, vol. 90, no. 2, pp. 535-44.

1997

de Lange, E.C., Danhof, M., de Boer, A.G., Breimer, D.D. , Methodological considerations of intracerebral microdialysis in pharmacokinetic studies on drug transport across the blood-brain barrier, Brain Res Brain Res Rev, vol. 25, no. 1, pp. 27-49.

1995

de Lange, E.C., Hesselink, M.B., Danhof, M., de Boer, A.G., Breimer, D.D. , The use of intracerebral microdialysis to determine changes in blood-brain barrier transport characteristics, Pharm Res, vol. 12, no. 1, pp. 129-33.

de Lange, E.C., Danhof, M., Zurcher, C., de Boer, A.G., Breimer, D.D. , Repeated microdialysis perfusions: periprobe tissue reactions and BBB permeability, Brain Res, vol. 702, no. 1-2, pp. 261-5.

de Lange, E.C., de Vries, J.D., Zurcher, C., Danhof, M., de Boer, A.G., Breimer, D.D. , The use of intracerebral microdialysis for the determination of pharmacokinetic profiles of anticancer drugs in tumor-bearing rat brain, Pharm Res, vol. 12, no. 12, pp. 1924-31.

1994

Mathot, R.A., Van den Aarsen, B.C., von Frijtag Drabble Kunzel, J.K., Danhof, M., Ijzerman, A.P. , Assessment of the enantiomeric purity of R- and S-N6-phenylisopropyladenosine (PIA): implications for adenosine receptor subclassification, Naunyn Schmiedebergs Arch Pharmacol, vol. 350, no. 1, pp. 109-12.

de Lange, E.C., Danhof, M., de Boer, A.G., Breimer, D.D. , Critical factors of intracerebral microdialysis as a technique to determine the pharmacokinetics of drugs in rat brain, Brain Res, vol. 666, no. 1, pp. 1-8.

1993

Van Bree, J.B., De Boer, A.G., Danhof, M., Breimer, D.D. , Drug transport across the blood-brain barrier. III. Mechanisms and methods to improve drug delivery to the central nervous system, Pharm World Sci, vol. 15, no. 1, pp. 2-9.

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