LACDR

Universiteit Leiden

List
Filter

Found 22 results. Export: Tagged | XML

Filters: keyword is Blood-Brain Barrier [Clear All Filters]

2008

Ravenstijn, P.G., Merlini, M., Hameetman, M., Murray, T.K., Ward, M.A., Lewis, H., Ball, G., Mottart, C., de Ville Goyet, C., Lemarchand, T., van Belle, K., O'Neill, M.J., Danhof, M., de Lange, E.C. , The exploration of rotenone as a toxin for inducing Parkinson's disease in rats, for application in BBB transport and PK-PD experiments, J Pharmacol Toxicol Methods, vol. 57, no. 2, pp. 114-30.

Geldof, M., Freijer, J., van Beijsterveldt, L., Danhof, M. , Pharmacokinetic modeling of non-linear brain distribution of fluvoxamine in the rat, Pharm Res, vol. 25, no. 4, pp. 792-804.

2005

Visser, C.C., Stevanovic, S., Voorwinden, L.H., van Bloois, L., Gaillard, P.J., Danhof, M., Crommelin, D.J., de Boer, A.G. , Targeting liposomes with protein drugs to the blood-brain barrier in vitro, Eur J Pharm Sci, vol. 25, no. 2-3, pp. 299-305.

2004

Schaddelee, M.P., Groenendaal, D., DeJongh, J., Cleypool, C.G., AP, I.J., De Boer, A.G., Danhof, M. , Population pharmacokinetic modeling of blood-brain barrier transport of synthetic adenosine A1 receptor agonists, J Pharmacol Exp Ther, vol. 311, no. 3, pp. 1138-46.

Visser, C.C., Stevanovic, S., Heleen Voorwinden, L., Gaillard, P.J., Crommelin, D.J., Danhof, M., De Boer, A.G. , Validation of the transferrin receptor for drug targeting to brain capillary endothelial cells in vitro, J Drug Target, vol. 12, no. 3, pp. 145-50.

2003

Bueters, T.J., AP, I.J., van Helden, H.P., Danhof, M. , Characterization of the pharmacokinetics, brain distribution, and therapeutic efficacy of the adenosine A1 receptor partial agonist 2'-deoxy-N6-cyclopentyladenosine in sarin-poisoned rats, Toxicol Appl Pharmacol, vol. 192, no. 1, pp. 86-94.

Schaddelee, M.P., Voorwinden, H.L., Groenendaal, D., Hersey, A., Ijzerman, A.P., Danhof, M., De Boer, A.G. , Blood-brain barrier transport of synthetic adenosine A1 receptor agonists in vitro: structure transport relationships, Eur J Pharm Sci, vol. 20, no. 3, pp. 347-56.

Schaddelee, M.P., Voorwinden, H.L., van Tilburg, E.W., Pateman, T.J., Ijzerman, A.P., Danhof, M., de Boer, A.G. , Functional role of adenosine receptor subtypes in the regulation of blood-brain barrier permeability: possible implications for the design of synthetic adenosine derivatives, Eur J Pharm Sci, vol. 19, no. 1, pp. 13-22.

2002

de Lange, E.C., Danhof, M. , Considerations in the use of cerebrospinal fluid pharmacokinetics to predict brain target concentrations in the clinical setting: implications of the barriers between blood and brain, Clin Pharmacokinet, vol. 41, no. 10, pp. 691-703.

1997

de Lange, E.C., Danhof, M., de Boer, A.G., Breimer, D.D. , Methodological considerations of intracerebral microdialysis in pharmacokinetic studies on drug transport across the blood-brain barrier, Brain Res Brain Res Rev, vol. 25, no. 1, pp. 27-49.

1995

de Lange, E.C., Hesselink, M.B., Danhof, M., de Boer, A.G., Breimer, D.D. , The use of intracerebral microdialysis to determine changes in blood-brain barrier transport characteristics, Pharm Res, vol. 12, no. 1, pp. 129-33.

de Lange, E.C., Danhof, M., Zurcher, C., de Boer, A.G., Breimer, D.D. , Repeated microdialysis perfusions: periprobe tissue reactions and BBB permeability, Brain Res, vol. 702, no. 1-2, pp. 261-5.

1994

de Lange, E.C., Danhof, M., de Boer, A.G., Breimer, D.D. , Critical factors of intracerebral microdialysis as a technique to determine the pharmacokinetics of drugs in rat brain, Brain Res, vol. 666, no. 1, pp. 1-8.

1993

Van Bree, J.B., De Boer, A.G., Danhof, M., Breimer, D.D. , Drug transport across the blood-brain barrier. III. Mechanisms and methods to improve drug delivery to the central nervous system, Pharm World Sci, vol. 15, no. 1, pp. 2-9.

de Lange, E.C., Danhof, M., de Boer, A.G., Breimer, D.D. , The use of intracerebral microdialysis to study blood-brain barrier transport in health, after modification and in disease, Adv Exp Med Biol, vol. 331, pp. 257-62.

1992

Van Bree, J.B., De Boer, A.G., Danhof, M., Breimer, D.D. , Drug transport across the blood--brain barrier. I. Anatomical and physiological aspects, Pharm Weekbl Sci, vol. 14, no. 5, pp. 305-10.

Van Bree, J.B., De Boer, A.G., Danhof, M., Breimer, D.D. , Drug transport across the blood-brain barrier. II. Experimental techniques to study drug transport, Pharm Weekbl Sci, vol. 14, no. 6, pp. 338-48.

1991

van Bree, J.B., Heijligers-Feijen, C.D., de Boer, A.G., Danhof, M., Breimer, D.D. , Stereoselective transport of baclofen across the blood-brain barrier in rats as determined by the unit impulse response methodology, Pharm Res, vol. 8, no. 2, pp. 259-62.

1990

van Bree, J.B., Tio, S., de Boer, A.G., Danhof, M., Verhoef, J.C., Breimer, D.D. , Transport of desglycinamide-arginine vasopressin across the blood-brain barrier in rats as evaluated by the unit impulse response methodology, Pharm Res, vol. 7, no. 3, pp. 293-8.

1989

van Bree, J.B., de Boer, A.G., Verhoef, J.C., Danhof, M., Breimer, D.D. , Transport of vasopressin fragments across the blood-brain barrier: in vitro studies using monolayer cultures of bovine brain endothelial cells, J Pharmacol Exp Ther, vol. 249, no. 3, pp. 901-5.

1988

Dingemanse, J., Polhuijs, M., Danhof, M. , Altered pharmacokinetic-pharmacodynamic relationship of heptabarbital in experimental renal failure in rats, J Pharmacol Exp Ther, vol. 246, no. 1, pp. 371-6.

van Bree, J.B., de Boer, A.G., Danhof, M., Ginsel, L.A., Breimer, D.D. , Characterization of an "in vitro" blood-brain barrier: effects of molecular size and lipophilicity on cerebrovascular endothelial transport rates of drugs, J Pharmacol Exp Ther, vol. 247, no. 3, pp. 1233-9.

LACDR