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Universiteit Leiden

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2008

Ravenstijn, P.G., Merlini, M., Hameetman, M., Murray, T.K., Ward, M.A., Lewis, H., Ball, G., Mottart, C., de Ville Goyet, C., Lemarchand, T., van Belle, K., O'Neill, M.J., Danhof, M., de Lange, E.C. , The exploration of rotenone as a toxin for inducing Parkinson's disease in rats, for application in BBB transport and PK-PD experiments, J Pharmacol Toxicol Methods, vol. 57, no. 2, pp. 114-30.

Geldof, M., Freijer, J. I, Peletier, L.A., van Beijsterveldt, L., Danhof, M. , Mechanistic model for the acute effect of fluvoxamine on 5-HT and 5-HIAA concentrations in rat frontal cortex, Eur J Pharm Sci, vol. 33, no. 3, pp. 217-29.

van Steeg, T.J., Freijer, J., Danhof, M., de Lange, E.C. , Mechanism-based pharmacodynamic modeling of S(-)-atenolol: estimation of in vivo affinity for the beta1-adrenoceptor with an agonist-antagonist interaction model, J Pharmacol Exp Ther, vol. 324, no. 3, pp. 1234-42.

Clinckers, R., Smolders, I, Michotte, Y., Ebinger, G., Danhof, M., Voskuyl, R.A., Della Pasqua, O. , Impact of efflux transporters and of seizures on the pharmacokinetics of oxcarbazepine metabolite in the rat brain, Br J Pharmacol, vol. 155, no. 7, pp. 1127-38.

Danhof, M., de Lange, E.C., Della Pasqua, O.E., Ploeger, B.A., Voskuyl, R.A. , Mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling in translational drug research, Trends Pharmacol Sci, vol. 29, no. 4, pp. 186-91.

Maas, H.J., Spruit, M.A., Danhof, M., Della Pasqua, O.E. , Relevance of absorption rate and lag time to the onset of action in migraine, Clin Pharmacokinet, vol. 47, no. 2, pp. 139-46.

2007

Geldof, M., Freijer, J., van Beijsterveldt, L., Vermote, P.C., Megens, A.A., Danhof, M. , Pharmacokinetic-pharmacodynamic modeling of the effect of fluvoxamine on p-chloroamphetamine-induced behavior, Eur J Pharm Sci, vol. 32, no. 3, pp. 200-8.

Yassen, A., Kan, J., Olofsen, E., Suidgeest, E., Dahan, A., Danhof, M. , Pharmacokinetic-pharmacodynamic modeling of the respiratory depressant effect of norbuprenorphine in rats, J Pharmacol Exp Ther, vol. 321, no. 2, pp. 598-607.

van Steeg, T.J., Krekels, E.H., Danhof, M., de Lange, E.C. , Reproducible and time-dependent modification of serum protein binding in Wistar Kyoto rats, J Pharmacol Toxicol Methods, vol. 56, no. 1, pp. 72-8.

Geldof, M., Freijer, J., van Beijsterveldt, L., Timmerman, P., Ahnaou, A., Drinkenburg, W.H., Danhof, M. , Population pharmacokinetic model of fluvoxamine in rats: utility for application in animal behavioral studies, Eur J Pharm Sci, vol. 30, no. 1, pp. 45-55.

Rolan, P., Danhof, M., Stanski, D., Peck, C. , Current issues relating to drug safety especially with regard to the use of biomarkers: a meeting report and progress update, Eur J Pharm Sci, vol. 30, no. 2, pp. 107-12.

Danhof, M., de Jongh, J., De Lange, E.C., Della Pasqua, O., Ploeger, B.A., Voskuyl, R.A. , Mechanism-based pharmacokinetic-pharmacodynamic modeling: biophase distribution, receptor theory, and dynamical systems analysis, Annu Rev Pharmacol Toxicol, vol. 47, pp. 357-400.

2006

Maas, H.J., Danhof, M., Della Pasqua, O. , A model-based approach to treatment comparison in acute migraine, Br J Clin Pharmacol, vol. 62, no. 5, pp. 591-600.

Yassen, A., Kan, J., Olofsen, E., Suidgeest, E., Dahan, A., Danhof, M. , Mechanism-based pharmacokinetic-pharmacodynamic modeling of the respiratory-depressant effect of buprenorphine and fentanyl in rats, J Pharmacol Exp Ther, vol. 319, no. 2, pp. 682-92.

Peeters, M.Y., Prins, S.A., Knibbe, C.A., DeJongh, J., van Schaik, R.H., van Dijk, M., van der Heiden, I.P., Tibboel, D., Danhof, M. , Propofol pharmacokinetics and pharmacodynamics for depth of sedation in nonventilated infants after major craniofacial surgery, Anesthesiology, vol. 104, no. 3, pp. 466-74.

Yassen, A., Olofsen, E., Romberg, R., Sarton, E., Danhof, M., Dahan, A. , Mechanism-based pharmacokinetic-pharmacodynamic modeling of the antinociceptive effect of buprenorphine in healthy volunteers, Anesthesiology, vol. 104, no. 6, pp. 1232-42.

Maas, H.J., Danhof, M., Della Pasqua, O.E. , Prediction of headache response in migraine treatment, Cephalalgia, vol. 26, no. 4, pp. 416-22.

Franciosi, L.G., Page, C.P., Celli, B.R., Cazzola, M., Walker, M.J., Danhof, M., Rabe, K.F., Della Pasqua, O.E. , Markers of disease severity in chronic obstructive pulmonary disease, Pulm Pharmacol Ther, vol. 19, no. 3, pp. 189-99.

Franciosi, L.G., Page, C.P., Celli, B.R., Cazzola, M., Walker, M.J., Danhof, M., Rabe, K.F., Della Pasqua, O.E. , Markers of exacerbation severity in chronic obstructive pulmonary disease, Respir Res, vol. 7, pp. 74.

2005

Danhof, M., Alvan, G., Dahl, S.G., Kuhlmann, J., Paintaud, G. , Mechanism-based pharmacokinetic-pharmacodynamic modeling-a new classification of biomarkers, Pharm Res, vol. 22, no. 9, pp. 1432-7.

Nugroho, A.K., Della-Pasqua, O., Danhof, M., Bouwstra, J.A. , Compartmental modeling of transdermal iontophoretic transport II: in vivo model derivation and application, Pharm Res, vol. 22, no. 3, pp. 335-46.

Knibbe, C.A., Zuideveld, K.P., Aarts, L.P., Kuks, P.F., Danhof, M. , Allometric relationships between the pharmacokinetics of propofol in rats, children and adults, Br J Clin Pharmacol, vol. 59, no. 6, pp. 705-11.

Yassen, A., Olofsen, E., Dahan, A., Danhof, M. , Pharmacokinetic-pharmacodynamic modeling of the antinociceptive effect of buprenorphine and fentanyl in rats: role of receptor equilibration kinetics, J Pharmacol Exp Ther, vol. 313, no. 3, pp. 1136-49.

Post, T.M., Freijer, J. I, DeJongh, J., Danhof, M. , Disease system analysis: basic disease progression models in degenerative disease, Pharm Res, vol. 22, no. 7, pp. 1038-49.

Huntjens, D.R., Danhof, M., Della Pasqua, O.E. , Pharmacokinetic-pharmacodynamic correlations and biomarkers in the development of COX-2 inhibitors, Rheumatology (Oxford), vol. 44, no. 7, pp. 846-59.

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