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Universiteit Leiden

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2008

van Steeg, T.J., Freijer, J., Danhof, M., de Lange, E.C. , Mechanism-based pharmacodynamic modeling of S(-)-atenolol: estimation of in vivo affinity for the beta1-adrenoceptor with an agonist-antagonist interaction model, J Pharmacol Exp Ther, vol. 324, no. 3, pp. 1234-42.

2007

van Steeg, T.J., Krekels, E.H., Danhof, M., de Lange, E.C. , Reproducible and time-dependent modification of serum protein binding in Wistar Kyoto rats, J Pharmacol Toxicol Methods, vol. 56, no. 1, pp. 72-8.

2006

Huntjens, D.R., Spalding, D.J., Danhof, M., Della Pasqua, O.E. , Correlation between in vitro and in vivo concentration-effect relationships of naproxen in rats and healthy volunteers, Br J Pharmacol, vol. 148, no. 4, pp. 396-404.

2005

Schaddelee, M.P., Read, K.D., Cleypool, C.G., Ijzerman, A.P., Danhof, M., de Boer, A.G. , Brain penetration of synthetic adenosine A1 receptor agonists in situ: role of the rENT1 nucleoside transporter and binding to blood constituents, Eur J Pharm Sci, vol. 24, no. 1, pp. 59-66.

Jonker, D.M., Visser, S.A., van der Graaf, P.H., Voskuyl, R.A., Danhof, M. , Towards a mechanism-based analysis of pharmacodynamic drug-drug interactions in vivo, Pharmacol Ther, vol. 106, no. 1, pp. 1-18.

2004

Zuideveld, K.P., Van der Graaf, P.H., Newgreen, D., Thurlow, R., Petty, N., Jordan, P., Peletier, L.A., Danhof, M. , Mechanism-based pharmacokinetic-pharmacodynamic modeling of 5-HT1A receptor agonists: estimation of in vivo affinity and intrinsic efficacy on body temperature in rats, J Pharmacol Exp Ther, vol. 308, no. 3, pp. 1012-20.

2003

Visser, S.A., Wolters, F.L., van der Graaf, P.H., Peletier, L.A., Danhof, M. , Dose-dependent EEG effects of zolpidem provide evidence for GABA(A) receptor subtype selectivity in vivo, J Pharmacol Exp Ther, vol. 304, no. 3, pp. 1251-7.

2002

Visser, S.A., Smulders, C.J., Reijers, B.P., Van der Graaf, P.H., Peletier, L.A., Danhof, M. , Mechanism-based pharmacokinetic-pharmacodynamic modeling of concentration-dependent hysteresis and biphasic electroencephalogram effects of alphaxalone in rats, J Pharmacol Exp Ther, vol. 302, no. 3, pp. 1158-67.

Tuk, B., van Gool, T., Danhof, M. , Mechanism-based pharmacodynamic modeling of the interaction of midazolam, bretazenil, and zolpidem with ethanol, J Pharmacokinet Pharmacodyn, vol. 29, no. 3, pp. 235-50.

Zuideveld, K.P., Treijtel, N., Maas, H.J., Gubbens-Stibbe, J.M., Peletier, L.A., van Der Graaf, P.H., Danhof, M. , A competitive interaction model predicts the effect of WAY-100,635 on the time course of R-(+)-8-hydroxy-2-(di-n-propylamino)tetralin-induced hypothermia, J Pharmacol Exp Ther, vol. 300, no. 1, pp. 330-8.

1999

Van der Graaf, P.H., Nilsson, J., Van Schaick, E.A., Danhof, M. , Multivariate quantitative structure-pharmacokinetic relationships (QSPKR) analysis of adenosine A1 receptor agonists in rat, J Pharm Sci, vol. 88, no. 3, pp. 306-12.

Snoeck, E., Jacqmin, P., Van Peer, A., Danhof, M. , A combined specific target site binding and pharmacokinetic model to explore the non-linear disposition of draflazine, J Pharmacokinet Biopharm, vol. 27, no. 3, pp. 257-81.

1998

Della Paschoa, O.E., Mandema, J.W., Voskuyl, R.A., Danhof, M. , Pharmacokinetic-pharmacodynamic modeling of the anticonvulsant and electroencephalogram effects of phenytoin in rats, J Pharmacol Exp Ther, vol. 284, no. 2, pp. 460-6.

1997

Van der Graaf, P.H., Danhof, M. , Analysis of drug-receptor interactions in vivo: a new approach in pharmacokinetic-pharmacodynamic modelling, Int J Clin Pharmacol Ther, vol. 35, no. 10, pp. 442-6.

Auler Junior, J.O., Espada, E.B., Crivelli, E., Quintavalle, T.B., Kurata, A., Stolf, N.A., Issy, A.M., Paschoa, O.E., Danhof, M., Breimer, D.D., Chamone, D.A., Santos, S.R. , Diclofenac plasma protein binding: PK-PD modelling in cardiac patients submitted to cardiopulmonary bypass, Braz J Med Biol Res, vol. 30, no. 3, pp. 369-74.

Snoeck, E., Piotrovskij, V., Jacqmin, P., Van Peer, A., Danhof, M., Ver Donck, K., Woestenborghs, R., Van Belle, H., Van Bortel, L., Van Gool, R., Dupont, A.G., Heykants, J. , Population analysis of the non linear red blood cell partitioning and the concentration-effect relationship of draflazine following various infusion rates, Br J Clin Pharmacol, vol. 43, no. 6, pp. 603-12.

Bol, C.J., AP, I.J., Danhof, M., Mandema, J.W. , Determination of dexmedetomidine in rat plasma by a sensitive [3H]clonidine radioreceptor assay, J Pharm Sci, vol. 86, no. 7, pp. 822-6.

1995

Appel, S., Mathot, R.A., Langemeijer, M.W., AP, I.J., Danhof, M. , Modelling of the pharmacodynamic interaction of an A1 adenosine receptor agonist and antagonist in vivo: N6-cyclopentyladenosine and 8-cyclopentyltheophylline, Br J Pharmacol, vol. 115, no. 7, pp. 1253-9.

Mathot, R.A., Van den Aarsen, B.C., Soudijn, W., Breimer, D.D., Ijzerman, A.P., Danhof, M. , Pharmacokinetic-pharmacodynamic modelling of the cardiovascular effects of R- and S-N6-phenylisopropyladenosine in conscious normotensive rats, J Pharmacol Exp Ther, vol. 273, no. 1, pp. 405-14.

1992

Danhof, M., de Boer, A., Magnani, H.N., Stiekema, J.C. , Pharmacokinetic considerations on Orgaran (Org 10172) therapy, Haemostasis, vol. 22, no. 2, pp. 73-84.

1985

Danhof, M., Hisaoka, M., Levy, G. , Kinetics of drug action in disease states. VI. Effect of experimental diabetes on phenobarbital concentrations in rats at onset of loss of righting reflex, J Pharmacol Exp Ther, vol. 232, no. 2, pp. 435-8.

Danhof, M., Levy, G. , Kinetics of drug action in disease states. IV. Effect of pregnancy on phenobarbital concentrations at onset of loss of righting reflex in rats, J Pharmacol Exp Ther, vol. 232, no. 2, pp. 426-9.

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