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Universiteit Leiden

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Filters: keyword is Anesthetics [Clear All Filters]

2008

Peeters, M.Y., Aarts, L.P., Boom, F.A., Bras, L.J., Tibboel, D., Danhof, M., Knibbe, C.A. , Pilot study on the influence of liver blood flow and cardiac output on the clearance of propofol in critically ill patients, Eur J Clin Pharmacol, vol. 64, no. 3, pp. 329-34.

2005

Knibbe, C.A., Zuideveld, K.P., Aarts, L.P., Kuks, P.F., Danhof, M. , Allometric relationships between the pharmacokinetics of propofol in rats, children and adults, Br J Clin Pharmacol, vol. 59, no. 6, pp. 705-11.

2004

Knibbe, C.A., Naber, H., Aarts, L.P., Kuks, P.F., Danhof, M. , Long-term sedation with propofol 60 mg ml(-1) vs. propofol 10 mg(-1) ml in critically ill, mechanically ventilated patients, Acta Anaesthesiol Scand, vol. 48, no. 3, pp. 302-7.

2003

Visser, S.A., Huntjens, D.R., van der Graaf, P.H., Peletier, L.A., Danhof, M. , Mechanism-based modeling of the pharmacodynamic interaction of alphaxalone and midazolam in rats, J Pharmacol Exp Ther, vol. 307, no. 2, pp. 765-75.

2002

Visser, S.A., Smulders, C.J., Reijers, B.P., Van der Graaf, P.H., Peletier, L.A., Danhof, M. , Mechanism-based pharmacokinetic-pharmacodynamic modeling of concentration-dependent hysteresis and biphasic electroencephalogram effects of alphaxalone in rats, J Pharmacol Exp Ther, vol. 302, no. 3, pp. 1158-67.

Visser, S.A., Gladdines, W.W., van der Graaf, P.H., Peletier, L.A., Danhof, M. , Neuroactive steroids differ in potency but not in intrinsic efficacy at the GABA(A) receptor in vivo, J Pharmacol Exp Ther, vol. 303, no. 2, pp. 616-26.

2000

Knibbe, C.A., Aarts, L.P., Kuks, P.F., Voortman, H.J., Lie, A.H.L., Bras, L.J., Danhof, M. , Pharmacokinetics and pharmacodynamics of propofol 6% SAZN versus propofol 1% SAZN and Diprivan-10 for short-term sedation following coronary artery bypass surgery, Eur J Clin Pharmacol, vol. 56, no. 1, pp. 89-95.

1999

Knibbe, C.A., Koster, V.S., Aarts, L.P., Langemeijer, H.J., Danhof, M. , Pilot study in humans on the pharmacokinetics and safety of propofol 6% SAZN, Pharm World Sci, vol. 21, no. 5, pp. 239-40.

Knibbe, C.A., Voortman, H.J., Aarts, L.P., Kuks, P.F., Lange, R., Langemeijer, H.J., Danhof, M. , Pharmacokinetics, induction of anaesthesia and safety characteristics of propofol 6% SAZN vs propofol 1% SAZN and Diprivan-10 after bolus injection, Br J Clin Pharmacol, vol. 47, no. 6, pp. 653-60.

Cox, E.H., Langemeijer, M.W., Gubbens-Stibbe, J.M., Muir, K.T., Danhof, M. , The comparative pharmacodynamics of remifentanil and its metabolite, GR90291, in a rat electroencephalographic model, Anesthesiology, vol. 90, no. 2, pp. 535-44.

1998

Cox, E.H., Knibbe, C.A., Koster, V.S., Langemeijer, M.W., Tukker, E.E., Lange, R., Kuks, P.F., Langemeijer, H.J., Lie, A.H.L., Danhof, M. , Influence of different fat emulsion-based intravenous formulations on the pharmacokinetics and pharmacodynamics of propofol, Pharm Res, vol. 15, no. 3, pp. 442-8.

1996

Danhof, M. , Applications of pharmacokinetic/pharmacodynamic research in rational drug development, Methods Find Exp Clin Pharmacol, vol. 18 Suppl C, pp. 53-4.

1992

Mandema, J.W., Danhof, M. , Electroencephalogram effect measures and relationships between pharmacokinetics and pharmacodynamics of centrally acting drugs, Clin Pharmacokinet, vol. 23, no. 3, pp. 191-215.

1990

Dingemanse, J., Hameter, B.M., Danhof, M. , Pharmacodynamics of tolerance development to the anesthetic and anticonvulsant effects of phenobarbital in rats, J Pharm Sci, vol. 79, no. 3, pp. 207-11.

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