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Universiteit Leiden

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2008

Groenendaal, D., Freijer, J., Rosier, A., de Mik, D., Nicholls, G., Hersey, A., Ayrton, A.D., Danhof, M., de Lange, E.C. , Pharmacokinetic/pharmacodynamic modelling of the EEG effects of opioids: the role of complex biophase distribution kinetics, Eur J Pharm Sci, vol. 34, no. 2-3, pp. 149-63.

Geldof, M., Freijer, J. I, van Beijsterveldt, L., Langlois, X., Danhof, M. , Pharmacokinetic-pharmacodynamic modelling of fluvoxamine 5-HT transporter occupancy in rat frontal cortex, Br J Pharmacol, vol. 154, no. 6, pp. 1369-78.

Yassen, A., Olofsen, E., Kan, J., Dahan, A., Danhof, M. , Pharmacokinetic-pharmacodynamic modeling of the effectiveness and safety of buprenorphine and fentanyl in rats, Pharm Res, vol. 25, no. 1, pp. 183-93.

Post, T.M., Freijer, J. I, Ploeger, B.A., Danhof, M. , Extensions to the visual predictive check to facilitate model performance evaluation, J Pharmacokinet Pharmacodyn, vol. 35, no. 2, pp. 185-202.

2007

van Steeg, T.J., Freijer, J., Danhof, M., de Lange, E.C. , Pharmacokinetic-pharmacodynamic modelling of S(-)-atenolol in rats: reduction of isoprenaline-induced tachycardia as a continuous pharmacodynamic endpoint, Br J Pharmacol, vol. 151, no. 3, pp. 356-66.

Groenendaal, D., Freijer, J., de Mik, D., Bouw, M.R., Danhof, M., de Lange, E.C. , Influence of biophase distribution and P-glycoprotein interaction on pharmacokinetic-pharmacodynamic modelling of the effects of morphine on the EEG, Br J Pharmacol, vol. 151, no. 5, pp. 713-20.

Groenendaal, D., Freijer, J., de Mik, D., Bouw, M.R., Danhof, M., de Lange, E.C. , Population pharmacokinetic modelling of non-linear brain distribution of morphine: influence of active saturable influx and P-glycoprotein mediated efflux, Br J Pharmacol, vol. 151, no. 5, pp. 701-12.

Yassen, A., Olofsen, E., van Dorp, E., Sarton, E., Teppema, L., Danhof, M., Dahan, A. , Mechanism-based pharmacokinetic-pharmacodynamic modelling of the reversal of buprenorphine-induced respiratory depression by naloxone : a study in healthy volunteers, Clin Pharmacokinet, vol. 46, no. 11, pp. 965-80.

2006

Swart, E.L., Zuideveld, K.P., de Jongh, J., Danhof, M., Thijs, L.G., van Strack Schijndel, R.M. , Population pharmacodynamic modelling of lorazepam- and midazolam-induced sedation upon long-term continuous infusion in critically ill patients, Eur J Clin Pharmacol, vol. 62, no. 3, pp. 185-94.

de Winter, W., DeJongh, J., Post, T., Ploeger, B., Urquhart, R., Moules, I, Eckland, D., Danhof, M. , A mechanism-based disease progression model for comparison of long-term effects of pioglitazone, metformin and gliclazide on disease processes underlying Type 2 Diabetes Mellitus, J Pharmacokinet Pharmacodyn, vol. 33, no. 3, pp. 313-43.

2005

Schaddelee, M.P., Collins, S.D., DeJongh, J., de Boer, A.G., Ijzerman, A.P., Danhof, M. , Pharmacokinetic/pharmacodynamic modelling of the anti-hyperalgesic and anti-nociceptive effect of adenosine A1 receptor partial agonists in neuropathic pain, Eur J Pharmacol, vol. 514, no. 2-3, pp. 131-40.

2004

Nugroho, A.K., Della Pasqua, O., Danhof, M., Bouwstra, J.A. , Compartmental modeling of transdermal iontophoretic transport: I. In vitro model derivation and application, Pharm Res, vol. 21, no. 11, pp. 1974-84.

Nugroho, A.K., Li, G.L., Danhof, M., Bouwstra, J.A. , Transdermal iontophoresis of rotigotine across human stratum corneum in vitro: influence of pH and NaCl concentration, Pharm Res, vol. 21, no. 5, pp. 844-50.

Schaddelee, M.P., Groenendaal, D., DeJongh, J., Cleypool, C.G., AP, I.J., De Boer, A.G., Danhof, M. , Population pharmacokinetic modeling of blood-brain barrier transport of synthetic adenosine A1 receptor agonists, J Pharmacol Exp Ther, vol. 311, no. 3, pp. 1138-46.

2003

Bueters, T.J., AP, I.J., van Helden, H.P., Danhof, M. , Characterization of the pharmacokinetics, brain distribution, and therapeutic efficacy of the adenosine A1 receptor partial agonist 2'-deoxy-N6-cyclopentyladenosine in sarin-poisoned rats, Toxicol Appl Pharmacol, vol. 192, no. 1, pp. 86-94.

Visser, S.A., Wolters, F.L., Gubbens-Stibbe, J.M., Tukker, E., Van Der Graaf, P.H., Peletier, L.A., Danhof, M. , Mechanism-based pharmacokinetic/pharmacodynamic modeling of the electroencephalogram effects of GABAA receptor modulators: in vitro-in vivo correlations, J Pharmacol Exp Ther, vol. 304, no. 1, pp. 88-101.

2002

Visser, S.A., Smulders, C.J., Reijers, B.P., Van der Graaf, P.H., Peletier, L.A., Danhof, M. , Mechanism-based pharmacokinetic-pharmacodynamic modeling of concentration-dependent hysteresis and biphasic electroencephalogram effects of alphaxalone in rats, J Pharmacol Exp Ther, vol. 302, no. 3, pp. 1158-67.

Visser, S.A., Gladdines, W.W., van der Graaf, P.H., Peletier, L.A., Danhof, M. , Neuroactive steroids differ in potency but not in intrinsic efficacy at the GABA(A) receptor in vivo, J Pharmacol Exp Ther, vol. 303, no. 2, pp. 616-26.

Zuideveld, K.P., Treijtel, N., Maas, H.J., Gubbens-Stibbe, J.M., Peletier, L.A., van Der Graaf, P.H., Danhof, M. , A competitive interaction model predicts the effect of WAY-100,635 on the time course of R-(+)-8-hydroxy-2-(di-n-propylamino)tetralin-induced hypothermia, J Pharmacol Exp Ther, vol. 300, no. 1, pp. 330-8.

2001

Parker, T.J., Della Pasqua, O.E., Loizillon, E., Chezaubernard, C., Jochemsen, R., Danhof, M. , Pharmacokinetic-pharmacodynamic modelling in the early development phase of anti-psychotics: a comparison of the effects of clozapine, S 16924 and S 18327 in the EEG model in rats, Br J Pharmacol, vol. 132, no. 1, pp. 151-8.

1999

Tuk, B., van Oostenbruggen, M.F., Herben, V.M., Mandema, J.W., Danhof, M. , Characterization of the pharmacodynamic interaction between parent drug and active metabolite in vivo: midazolam and alpha-OH-midazolam, J Pharmacol Exp Ther, vol. 289, no. 2, pp. 1067-74.

Cleton, A., Mazee, D., Voskuyl, R.A., Danhof, M. , Rate of change of blood concentrations is a major determinant of the pharmacodynamics of midazolam in rats, Br J Pharmacol, vol. 127, no. 1, pp. 227-35.

1996

Vinks, A.A., Mouton, J.W., Touw, D.J., Heijerman, H.G., Danhof, M., Bakker, W. , Population pharmacokinetics of ceftazidime in cystic fibrosis patients analyzed by using a nonparametric algorithm and optimal sampling strategy, Antimicrob Agents Chemother, vol. 40, no. 5, pp. 1091-7.

1991

Veng-Pedersen, P., Mandema, J.W., Danhof, M. , A system approach to pharmacodynamics. III: An algorithm and computer program, COLAPS, for pharmacodynamic modeling, J Pharm Sci, vol. 80, no. 5, pp. 488-95.

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