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Universiteit Leiden

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1999

Cleton, A., de Greef, H.J., Edelbroek, P.M., Voskuyl, R.A., Danhof, M. , Application of a combined "effect compartment/indirect response model" to the central nervous system effects of tiagabine in the rat, J Pharmacokinet Biopharm, vol. 27, no. 3, pp. 301-23.

Cleton, A., de Greef, H.J., Edelbroek, P.M., Voskuyl, R.A., Danhof, M. , Stereoselective central nervous system effects of the R- and S-isomers of the GABA uptake blocker N-(4, 4-di-(3-methylthien-2-yl)but-3-enyl) nipecotic acid in the rat, Br J Pharmacol, vol. 128, no. 8, pp. 1651-8.

Van der Graaf, P.H., Van Schaick, E.A., Visser, S.A., De Greef, H.J., Ijzerman, A.P., Danhof, M. , Mechanism-based pharmacokinetic-pharmacodynamic modeling of antilipolytic effects of adenosine A(1) receptor agonists in rats: prediction of tissue-dependent efficacy in vivo, J Pharmacol Exp Ther, vol. 290, no. 2, pp. 702-9.

1997

van Schaick, E.A., de Greef, H.J., Langemeijer, M.W., Sheehan, M.J., AP, I.J., Danhof, M. , Pharmacokinetic-pharmacodynamic modelling of the anti-lipolytic and anti-ketotic effects of the adenosine A1-receptor agonist N6-(p-sulphophenyl)adenosine in rats, Br J Pharmacol, vol. 122, no. 3, pp. 525-33.

van Schaick, E.A., de Greef, H.J., Ijzerman, A.P., Danhof, M. , Physiological indirect effect modeling of the antilipolytic effects of adenosine A1-receptor agonists, J Pharmacokinet Biopharm, vol. 25, no. 6, pp. 673-94.

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