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Universiteit Leiden

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2009

Liefaard, L.C., Ploeger, B.A., Molthoff, C.F., de Jong, H.W., Dijkstra, J., van der Weerd, L., Lammertsma, A.A., Danhof, M., Voskuyl, R.A. , Changes in GABAA receptor properties in amygdala kindled animals: in vivo studies using [11C]flumazenil and positron emission tomography, Epilepsia, vol. 50, no. 1, pp. 88-98.

Muller, A.E., Oostvogel, P.M., DeJongh, J., Mouton, J.W., Steegers, E.A., Dorr, P.J., Danhof, M., Voskuyl, R.A. , Pharmacokinetics of amoxicillin in maternal, umbilical cord, and neonatal sera, Antimicrob Agents Chemother, vol. 53, no. 4, pp. 1574-80.

2008

Muller, A.E., DeJongh, J., Oostvogel, P.M., Voskuyl, R.A., Dorr, P.J., Danhof, M., Mouton, J.W. , Amoxicillin pharmacokinetics in pregnant women with preterm premature rupture of the membranes, Am J Obstet Gynecol, vol. 198, no. 1, pp. 108 e1-6.

Clinckers, R., Smolders, I, Michotte, Y., Ebinger, G., Danhof, M., Voskuyl, R.A., Della Pasqua, O. , Impact of efflux transporters and of seizures on the pharmacokinetics of oxcarbazepine metabolite in the rat brain, Br J Pharmacol, vol. 155, no. 7, pp. 1127-38.

Muller, A.E., Dorr, P.J., Mouton, J.W., De Jongh, J., Oostvogel, P.M., Steegers, E.A., Voskuyl, R.A., Danhof, M. , The influence of labour on the pharmacokinetics of intravenously administered amoxicillin in pregnant women, Br J Clin Pharmacol, vol. 66, no. 6, pp. 866-74.

Danhof, M., de Lange, E.C., Della Pasqua, O.E., Ploeger, B.A., Voskuyl, R.A. , Mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling in translational drug research, Trends Pharmacol Sci, vol. 29, no. 4, pp. 186-91.

2007

Jonker, D.M., Voskuyl, R.A., Danhof, M. , Synergistic combinations of anticonvulsant agents: what is the evidence from animal experiments?, Epilepsia, vol. 48, no. 3, pp. 412-34.

Liefaard, L.C., Gunput, R.A., Danhof, M., Voskuyl, R.A. , Decreased Efficacy of GABAA-receptor modulation by midazolam in the kainate model of temporal lobe epilepsy, Epilepsia, vol. 48, no. 7, pp. 1378-87.

Danhof, M., de Jongh, J., De Lange, E.C., Della Pasqua, O., Ploeger, B.A., Voskuyl, R.A. , Mechanism-based pharmacokinetic-pharmacodynamic modeling: biophase distribution, receptor theory, and dynamical systems analysis, Annu Rev Pharmacol Toxicol, vol. 47, pp. 357-400.

2005

Liefaard, L.C., Ploeger, B.A., Molthoff, C.F., Boellaard, R., Lammertsma, A.A., Danhof, M., Voskuyl, R.A. , Population pharmacokinetic analysis for simultaneous determination of B (max) and K (D) in vivo by positron emission tomography, Mol Imaging Biol, vol. 7, no. 6, pp. 411-21.

Jonker, D.M., Visser, S.A., van der Graaf, P.H., Voskuyl, R.A., Danhof, M. , Towards a mechanism-based analysis of pharmacodynamic drug-drug interactions in vivo, Pharmacol Ther, vol. 106, no. 1, pp. 1-18.

2004

Jonker, D.M., Voskuyl, R.A., Danhof, M. , Pharmacodynamic analysis of the anticonvulsant effects of tiagabine and lamotrigine in combination in the rat, Epilepsia, vol. 45, no. 5, pp. 424-35.

2003

Jonker, D.M., van de Mheen, C., Eilers, P.H., Kruk, M.R., Voskuyl, R.A., Danhof, M. , Anticonvulsant drugs differentially suppress individual ictal signs: a pharmacokinetic/pharmacodynamic analysis in the cortical stimulation model in the rat, Behav Neurosci, vol. 117, no. 5, pp. 1076-85.

Jonker, D.M., Vermeij, D.A., Edelbroek, P.M., Voskuyl, R.A., Piotrovsky, V.K., Danhof, M. , Pharmacodynamic analysis of the interaction between tiagabine and midazolam with an allosteric model that incorporates signal transduction, Epilepsia, vol. 44, no. 3, pp. 329-38.

2000

Cleton, A., Odman, J., Van der Graaf, P.H., Ghijsen, W., Voskuyl, R., Danhof, M. , Mechanism-based modeling of functional adaptation upon chronic treatment with midazolam, Pharm Res, vol. 17, no. 3, pp. 321-7.

Della Paschoa, O.E., Hoogerkamp, A., Edelbroek, P.M., Voskuyl, R.A., Danhof, M. , Pharmacokinetic-pharmacodynamic correlation of lamotrigine, flunarizine, loreclezole, CGP40116 and CGP39551 in the cortical stimulation model, Epilepsy Res, vol. 40, no. 1, pp. 41-52.

Cleton, A., Altorf, B.A., Voskuyl, R.A., Danhof, M. , Effect of amygdala kindling on the central nervous system effects of tiagabine: EEG effects versus brain GABA levels, Br J Pharmacol, vol. 130, no. 5, pp. 1037-44.

Cleton, A., Altorf, B.A., Voskuyl, R.A., Danhof, M. , Pharmacokinetic-pharmacodynamic modelling of tiagabine CNS effects upon chronic treatment in rats: lack of change in concentration-EEG effect relationship, Eur J Pharm Sci, vol. 12, no. 2, pp. 141-50.

1999

Cleton, A., Van der Graaf, P.H., Ghijsen, W., Voskuyl, R., Danhof, M. , Mechanism-based modeling of adaptive changes in the pharmacodynamics of midazolam in the kindling model of epilepsy, Pharm Res, vol. 16, no. 11, pp. 1702-9.

Cleton, A., Mazee, D., Voskuyl, R.A., Danhof, M. , Rate of change of blood concentrations is a major determinant of the pharmacodynamics of midazolam in rats, Br J Pharmacol, vol. 127, no. 1, pp. 227-35.

Cleton, A., de Greef, H.J., Edelbroek, P.M., Voskuyl, R.A., Danhof, M. , Application of a combined "effect compartment/indirect response model" to the central nervous system effects of tiagabine in the rat, J Pharmacokinet Biopharm, vol. 27, no. 3, pp. 301-23.

Cleton, A., de Greef, H.J., Edelbroek, P.M., Voskuyl, R.A., Danhof, M. , Stereoselective central nervous system effects of the R- and S-isomers of the GABA uptake blocker N-(4, 4-di-(3-methylthien-2-yl)but-3-enyl) nipecotic acid in the rat, Br J Pharmacol, vol. 128, no. 8, pp. 1651-8.

1998

Cleton, A., Voskuyl, R.A., Danhof, M. , Adaptive changes in the pharmacodynamics of midazolam in different experimental models of epilepsy: kindling, cortical stimulation and genetic absence epilepsy, Br J Pharmacol, vol. 125, no. 4, pp. 615-20.

Della Paschoa, O.E., Kruk, M.R., Hamstra, R., Voskuyl, R.A., Danhof, M. , Pharmacodynamic interaction between phenytoin and sodium valproate changes seizure thresholds and pattern, Br J Pharmacol, vol. 125, no. 5, pp. 997-1004.

Della Paschoa, O.E., Mandema, J.W., Voskuyl, R.A., Danhof, M. , Pharmacokinetic-pharmacodynamic modeling of the anticonvulsant and electroencephalogram effects of phenytoin in rats, J Pharmacol Exp Ther, vol. 284, no. 2, pp. 460-6.

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