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- 2009
Changes in GABAA receptor properties in amygdala kindled animals: in vivo studies using [11C]flumazenil and positron emission tomography,
Epilepsia, vol. 50, no. 1, pp. 88-98.
Pharmacokinetics of amoxicillin in maternal, umbilical cord, and neonatal sera,
Antimicrob Agents Chemother, vol. 53, no. 4, pp. 1574-80.
- 2008
Amoxicillin pharmacokinetics in pregnant women with preterm premature rupture of the membranes,
Am J Obstet Gynecol, vol. 198, no. 1, pp. 108 e1-6.
Impact of efflux transporters and of seizures on the pharmacokinetics of oxcarbazepine metabolite in the rat brain,
Br J Pharmacol, vol. 155, no. 7, pp. 1127-38.
The influence of labour on the pharmacokinetics of intravenously administered amoxicillin in pregnant women,
Br J Clin Pharmacol, vol. 66, no. 6, pp. 866-74.
Mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling in translational drug research,
Trends Pharmacol Sci, vol. 29, no. 4, pp. 186-91.
- 2007
Synergistic combinations of anticonvulsant agents: what is the evidence from animal experiments?,
Epilepsia, vol. 48, no. 3, pp. 412-34.
Decreased Efficacy of GABAA-receptor modulation by midazolam in the kainate model of temporal lobe epilepsy,
Epilepsia, vol. 48, no. 7, pp. 1378-87.
Mechanism-based pharmacokinetic-pharmacodynamic modeling: biophase distribution, receptor theory, and dynamical systems analysis,
Annu Rev Pharmacol Toxicol, vol. 47, pp. 357-400.
- 2005
Population pharmacokinetic analysis for simultaneous determination of B (max) and K (D) in vivo by positron emission tomography,
Mol Imaging Biol, vol. 7, no. 6, pp. 411-21.
Towards a mechanism-based analysis of pharmacodynamic drug-drug interactions in vivo,
Pharmacol Ther, vol. 106, no. 1, pp. 1-18.
- 2004
Pharmacodynamic analysis of the anticonvulsant effects of tiagabine and lamotrigine in combination in the rat,
Epilepsia, vol. 45, no. 5, pp. 424-35.
- 2003
Anticonvulsant drugs differentially suppress individual ictal signs: a pharmacokinetic/pharmacodynamic analysis in the cortical stimulation model in the rat,
Behav Neurosci, vol. 117, no. 5, pp. 1076-85.
Pharmacodynamic analysis of the interaction between tiagabine and midazolam with an allosteric model that incorporates signal transduction,
Epilepsia, vol. 44, no. 3, pp. 329-38.
- 2000
Mechanism-based modeling of functional adaptation upon chronic treatment with midazolam,
Pharm Res, vol. 17, no. 3, pp. 321-7.
Pharmacokinetic-pharmacodynamic correlation of lamotrigine, flunarizine, loreclezole, CGP40116 and CGP39551 in the cortical stimulation model,
Epilepsy Res, vol. 40, no. 1, pp. 41-52.
Effect of amygdala kindling on the central nervous system effects of tiagabine: EEG effects versus brain GABA levels,
Br J Pharmacol, vol. 130, no. 5, pp. 1037-44.
Pharmacokinetic-pharmacodynamic modelling of tiagabine CNS effects upon chronic treatment in rats: lack of change in concentration-EEG effect relationship,
Eur J Pharm Sci, vol. 12, no. 2, pp. 141-50.
- 1999
Mechanism-based modeling of adaptive changes in the pharmacodynamics of midazolam in the kindling model of epilepsy,
Pharm Res, vol. 16, no. 11, pp. 1702-9.
Rate of change of blood concentrations is a major determinant of the pharmacodynamics of midazolam in rats,
Br J Pharmacol, vol. 127, no. 1, pp. 227-35.
Application of a combined "effect compartment/indirect response model" to the central nervous system effects of tiagabine in the rat,
J Pharmacokinet Biopharm, vol. 27, no. 3, pp. 301-23.
Stereoselective central nervous system effects of the R- and S-isomers of the GABA uptake blocker N-(4, 4-di-(3-methylthien-2-yl)but-3-enyl) nipecotic acid in the rat,
Br J Pharmacol, vol. 128, no. 8, pp. 1651-8.
- 1998
Adaptive changes in the pharmacodynamics of midazolam in different experimental models of epilepsy: kindling, cortical stimulation and genetic absence epilepsy,
Br J Pharmacol, vol. 125, no. 4, pp. 615-20.
Pharmacodynamic interaction between phenytoin and sodium valproate changes seizure thresholds and pattern,
Br J Pharmacol, vol. 125, no. 5, pp. 997-1004.
Pharmacokinetic-pharmacodynamic modeling of the anticonvulsant and electroencephalogram effects of phenytoin in rats,
J Pharmacol Exp Ther, vol. 284, no. 2, pp. 460-6.



