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Universiteit Leiden

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2005

Visser, C.C., Stevanovic, S., Voorwinden, L.H., van Bloois, L., Gaillard, P.J., Danhof, M., Crommelin, D.J., de Boer, A.G. , Targeting liposomes with protein drugs to the blood-brain barrier in vitro, Eur J Pharm Sci, vol. 25, no. 2-3, pp. 299-305.

Jonker, D.M., Visser, S.A., van der Graaf, P.H., Voskuyl, R.A., Danhof, M. , Towards a mechanism-based analysis of pharmacodynamic drug-drug interactions in vivo, Pharmacol Ther, vol. 106, no. 1, pp. 1-18.

2004

Visser, C.C., Voorwinden, L.H., Crommelin, D.J., Danhof, M., de Boer, A.G. , Characterization and modulation of the transferrin receptor on brain capillary endothelial cells, Pharm Res, vol. 21, no. 5, pp. 761-9.

Visser, C.C., Stevanovic, S., Heleen Voorwinden, L., Gaillard, P.J., Crommelin, D.J., Danhof, M., De Boer, A.G. , Validation of the transferrin receptor for drug targeting to brain capillary endothelial cells in vitro, J Drug Target, vol. 12, no. 3, pp. 145-50.

Visser, C.C., Voorwinden, L.H., Harders, L.R., Eloualid, M., van Bloois, L., Crommelin, D.J., Danhof, M., de Boer, A.G. , Coupling of metal containing homing devices to liposomes via a maleimide linker: use of TCEP to stabilize thiol-groups without scavenging metals, J Drug Target, vol. 12, no. 9-10, pp. 569-73.

2003

Visser, S.A., Huntjens, D.R., van der Graaf, P.H., Peletier, L.A., Danhof, M. , Mechanism-based modeling of the pharmacodynamic interaction of alphaxalone and midazolam in rats, J Pharmacol Exp Ther, vol. 307, no. 2, pp. 765-75.

Visser, S.A., Wolters, F.L., van der Graaf, P.H., Peletier, L.A., Danhof, M. , Dose-dependent EEG effects of zolpidem provide evidence for GABA(A) receptor subtype selectivity in vivo, J Pharmacol Exp Ther, vol. 304, no. 3, pp. 1251-7.

Visser, S.A., Wolters, F.L., Gubbens-Stibbe, J.M., Tukker, E., Van Der Graaf, P.H., Peletier, L.A., Danhof, M. , Mechanism-based pharmacokinetic/pharmacodynamic modeling of the electroencephalogram effects of GABAA receptor modulators: in vitro-in vivo correlations, J Pharmacol Exp Ther, vol. 304, no. 1, pp. 88-101.

2002

Visser, S.A., Smulders, C.J., Reijers, B.P., Van der Graaf, P.H., Peletier, L.A., Danhof, M. , Mechanism-based pharmacokinetic-pharmacodynamic modeling of concentration-dependent hysteresis and biphasic electroencephalogram effects of alphaxalone in rats, J Pharmacol Exp Ther, vol. 302, no. 3, pp. 1158-67.

Visser, S.A., Gladdines, W.W., van der Graaf, P.H., Peletier, L.A., Danhof, M. , Neuroactive steroids differ in potency but not in intrinsic efficacy at the GABA(A) receptor in vivo, J Pharmacol Exp Ther, vol. 303, no. 2, pp. 616-26.

Danhof, M., Visser, S.A. , Pharmaco-electroencephalography and pharmacokinetic-pharmacodynamic modeling in drug development: focus on preclinical steps, Methods Find Exp Clin Pharmacol, vol. 24 Suppl D, pp. 127-8.

2000

Visser, S.A., Smulders, C.J., Gladdines, W.W., Irth, H., van der Graaf, P.H., Danhof, M. , High-performance liquid chromatography of the neuroactive steroids alphaxalone and pregnanolone in plasma using dansyl hydrazine as fluorescent label: application to a pharmacokinetic-pharmacodynamic study in rats, J Chromatogr B Biomed Sci Appl, vol. 745, no. 2, pp. 357-63.

1999

Van der Graaf, P.H., Van Schaick, E.A., Visser, S.A., De Greef, H.J., Ijzerman, A.P., Danhof, M. , Mechanism-based pharmacokinetic-pharmacodynamic modeling of antilipolytic effects of adenosine A(1) receptor agonists in rats: prediction of tissue-dependent efficacy in vivo, J Pharmacol Exp Ther, vol. 290, no. 2, pp. 702-9.

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