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Universiteit Leiden

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2008

van Steeg, T.J., Freijer, J., Danhof, M., de Lange, E.C. , Mechanism-based pharmacodynamic modeling of S(-)-atenolol: estimation of in vivo affinity for the beta1-adrenoceptor with an agonist-antagonist interaction model, J Pharmacol Exp Ther, vol. 324, no. 3, pp. 1234-42.

van Steeg, T.J., Boralli, V.B., Krekels, E.H., Slijkerman, P., Freijer, J., Danhof, M., de Lange, E.C. , Influence of plasma protein binding on pharmacodynamics: Estimation of in vivo receptor affinities of beta blockers using a new mechanism-based PK-PD modelling approach, J Pharm Sci.

2007

van Steeg, T.J., Freijer, J., Danhof, M., de Lange, E.C. , Pharmacokinetic-pharmacodynamic modelling of S(-)-atenolol in rats: reduction of isoprenaline-induced tachycardia as a continuous pharmacodynamic endpoint, Br J Pharmacol, vol. 151, no. 3, pp. 356-66.

van Steeg, T.J., Krekels, E.H., Danhof, M., de Lange, E.C. , Reproducible and time-dependent modification of serum protein binding in Wistar Kyoto rats, J Pharmacol Toxicol Methods, vol. 56, no. 1, pp. 72-8.

2005

Li, G.L., de Vries, J.J., van Steeg, T.J., van den Bussche, H., Maas, H.J., Reeuwijk, H.J., Danhof, M., Bouwstra, J.A., van Laar, T. , Transdermal iontophoretic delivery of apomorphine in patients improved by surfactant formulation pretreatment, J Control Release, vol. 101, no. 1-3, pp. 199-208.

Li, G.L., Van Steeg, T.J., Putter, H., Van Der Spek, J., Pavel, S., Danhof, M., Bouwstra, J.A. , Cutaneous side-effects of transdermal iontophoresis with and without surfactant pretreatment: a single-blinded, randomized controlled trial, Br J Dermatol, vol. 153, no. 2, pp. 404-12.

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