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Universiteit Leiden

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1999

Van der Graaf, P.H., Nilsson, J., Van Schaick, E.A., Danhof, M. , Multivariate quantitative structure-pharmacokinetic relationships (QSPKR) analysis of adenosine A1 receptor agonists in rat, J Pharm Sci, vol. 88, no. 3, pp. 306-12.

Van der Graaf, P.H., Van Schaick, E.A., Visser, S.A., De Greef, H.J., Ijzerman, A.P., Danhof, M. , Mechanism-based pharmacokinetic-pharmacodynamic modeling of antilipolytic effects of adenosine A(1) receptor agonists in rats: prediction of tissue-dependent efficacy in vivo, J Pharmacol Exp Ther, vol. 290, no. 2, pp. 702-9.

1998

van Schaick, E.A., Zuideveld, K.P., Tukker, H.E., Langemeijer, M.W., Ijzerman, A.P., Danhof, M. , Metabolic and cardiovascular effects of the adenosine A1 receptor agonist N6-(p-sulfophenyl)adenosine in diabetic Zucker rats: influence of the disease on the selectivity of action, J Pharmacol Exp Ther, vol. 287, no. 1, pp. 21-30.

van Schaick, E.A., Tukker, H.E., Roelen, H.C., AP, I.J., Danhof, M. , Selectivity of action of 8-alkylamino analogues of N6-cyclopentyladenosine in vivo: haemodynamic versus anti-lipolytic responses in rats, Br J Pharmacol, vol. 124, no. 3, pp. 607-18.

1997

van Schaick, E.A., de Greef, H.J., Langemeijer, M.W., Sheehan, M.J., AP, I.J., Danhof, M. , Pharmacokinetic-pharmacodynamic modelling of the anti-lipolytic and anti-ketotic effects of the adenosine A1-receptor agonist N6-(p-sulphophenyl)adenosine in rats, Br J Pharmacol, vol. 122, no. 3, pp. 525-33.

Van Schaick, E.A., Math-ot, R.A., Gubbens-Stibbe, J.M., Langemeijer, M.W., Roelen, H.C., Ijzerman, A.P., Danhof, M. , 8-Alkylamino-substituted analogs of N6-cyclopentyladenosine are partial agonists for the cardiovascular adenosine A1 receptors in vivo, J Pharmacol Exp Ther, vol. 283, no. 2, pp. 800-8.

Van Der Graaf, P.H., Van Schaick, E.A., Math-ot, R.A., Ijzerman, A.P., Danhof, M. , Mechanism-based pharmacokinetic-pharmacodynamic modeling of the effects of N6-cyclopentyladenosine analogs on heart rate in rat: estimation of in vivo operational affinity and efficacy at adenosine A1 receptors, J Pharmacol Exp Ther, vol. 283, no. 2, pp. 809-16.

van Schaick, E.A., de Greef, H.J., Ijzerman, A.P., Danhof, M. , Physiological indirect effect modeling of the antilipolytic effects of adenosine A1-receptor agonists, J Pharmacokinet Biopharm, vol. 25, no. 6, pp. 673-94.

van Schaick, E.A., Kulkarni, C., von Frijtag Drabbe Kunzel, J.K., Mathot, R.A., Cristalli, G., AP, I.J., Danhof, M. , Time course of action of three adenosine A1 receptor agonists with differing lipophilicity in rats: comparison of pharmacokinetic, haemodynamic and EEG effects, Naunyn Schmiedebergs Arch Pharmacol, vol. 356, no. 6, pp. 827-37.

1996

Van Schaick, E.A., Jacobson, K.A., Kim, H.O., AP, I.J., Danhof, M. , Hemodynamic effects and histamine release elicited by the selective adenosine A3 receptor agonist 2-Cl-IB-MECA in conscious rats, Eur J Pharmacol, vol. 308, no. 3, pp. 311-4.

1994

Mathot, R.A., van Schaick, E.A., Langemeijer, M.W., Soudijn, W., Breimer, D.D., Ijzerman, A.P., Danhof, M. , Pharmacokinetic-pharmacodynamic relationship of the cardiovascular effects of adenosine A1 receptor agonist N6-cyclopentyladenosine in the rat, J Pharmacol Exp Ther, vol. 268, no. 2, pp. 616-24.

1993

Mathot, R.A., Appel, S., van Schaick, E.A., Soudijn, W., AP, I.J., Danhof, M. , High-performance liquid chromatography of the adenosine A1 agonist N6-cyclopentyladenosine and the A1 antagonist 8-cyclopentyltheophylline and its application in a pharmacokinetic study in rats, J Chromatogr, vol. 620, no. 1, pp. 113-20.

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