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Universiteit Leiden

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2003

Visser, S.A., Wolters, F.L., Gubbens-Stibbe, J.M., Tukker, E., Van Der Graaf, P.H., Peletier, L.A., Danhof, M. , Mechanism-based pharmacokinetic/pharmacodynamic modeling of the electroencephalogram effects of GABAA receptor modulators: in vitro-in vivo correlations, J Pharmacol Exp Ther, vol. 304, no. 1, pp. 88-101.

2000

Garrido, M., Gubbens-Stibbe, J., Tukker, E., Cox, E., von Frijtag, J., Kunzel, D., A, I.J., Danhof, M., van der Graaf, P.H. , Pharmacokinetic-pharmacodynamic analysis of the EEG effect of alfentanil in rats following beta-funaltrexamine-induced mu-opioid receptor "knockdown" in vivo, Pharm Res, vol. 17, no. 6, pp. 653-9.

1998

van Schaick, E.A., Zuideveld, K.P., Tukker, H.E., Langemeijer, M.W., Ijzerman, A.P., Danhof, M. , Metabolic and cardiovascular effects of the adenosine A1 receptor agonist N6-(p-sulfophenyl)adenosine in diabetic Zucker rats: influence of the disease on the selectivity of action, J Pharmacol Exp Ther, vol. 287, no. 1, pp. 21-30.

Cox, E.H., Knibbe, C.A., Koster, V.S., Langemeijer, M.W., Tukker, E.E., Lange, R., Kuks, P.F., Langemeijer, H.J., Lie, A.H.L., Danhof, M. , Influence of different fat emulsion-based intravenous formulations on the pharmacokinetics and pharmacodynamics of propofol, Pharm Res, vol. 15, no. 3, pp. 442-8.

van Schaick, E.A., Tukker, H.E., Roelen, H.C., AP, I.J., Danhof, M. , Selectivity of action of 8-alkylamino analogues of N6-cyclopentyladenosine in vivo: haemodynamic versus anti-lipolytic responses in rats, Br J Pharmacol, vol. 124, no. 3, pp. 607-18.

1997

Cox, E.H., Van Hemert, J.G., Tukker, E.J., Danhof, M. , Pharmacokinetic-pharmacodynamic modelling of the EEG effect of alfentanil in rats, J Pharmacol Toxicol Methods, vol. 38, no. 2, pp. 99-108.

1992

Mandema, J.W., Tukker, E., Danhof, M. , In vivo characterization of the pharmacodynamic interaction of a benzodiazepine agonist and antagonist: midazolam and flumazenil, J Pharmacol Exp Ther, vol. 260, no. 1, pp. 36-44.

Mandema, J.W., Heijligers-Feijen, C.D., Tukker, E., De Boer, A.G., Danhof, M. , Modeling of the effect site equilibration kinetics and pharmacodynamics of racemic baclofen and its enantiomers using quantitative EEG effect measures, J Pharmacol Exp Ther, vol. 261, no. 1, pp. 88-95.

1991

Mandema, J.W., Tukker, E., Danhof, M. , Pharmacokinetic-pharmacodynamic modelling of the EEG effects of midazolam in individual rats: influence of rate and route of administration, Br J Pharmacol, vol. 102, no. 3, pp. 663-8.

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