LACDR

Universiteit Leiden

List
Filter

Found 16 results. Export: Tagged | XML

Filters: author is Mathot [Clear All Filters]

2006

Peeters, M.Y., Prins, S.A., Knibbe, C.A., Dejongh, J., Mathot, R.A., Warris, C., van Schaik, R.H., Tibboel, D., Danhof, M. , Pharmacokinetics and pharmacodynamics of midazolam and metabolites in nonventilated infants after craniofacial surgery, Anesthesiology, vol. 105, no. 6, pp. 1135-46.

1997

van Schaick, E.A., Kulkarni, C., von Frijtag Drabbe Kunzel, J.K., Mathot, R.A., Cristalli, G., AP, I.J., Danhof, M. , Time course of action of three adenosine A1 receptor agonists with differing lipophilicity in rats: comparison of pharmacokinetic, haemodynamic and EEG effects, Naunyn Schmiedebergs Arch Pharmacol, vol. 356, no. 6, pp. 827-37.

1996

Mathot, R.A., Wenden, E.M., Soudijn, W., Breimer, D.D., Ijzerman, A.P., Danhof, M. , Partial agonism of the nonselective adenosine receptor agonist 8-butylaminoadenosine at the A1 receptor in vivo, J Pharmacol Exp Ther, vol. 279, no. 3, pp. 1439-46.

1995

van der Wenden, E.M., von Frijtag Drabbe Kunzel, J.K., Mathot, R.A., Danhof, M., AP, I.J., Soudijn, W. , Ribose-modified adenosine analogues as potential partial agonists for the adenosine receptor, J Med Chem, vol. 38, no. 20, pp. 4000-6.

Mathot, R.A., Van der Wenden, E.M., Soudijn, W., AP, I.J., Danhof, M. , Deoxyribose analogues of N6-cyclopentyladenosine (CPA): partial agonists at the adenosine A1 receptor in vivo, Br J Pharmacol, vol. 116, no. 3, pp. 1957-64.

Mathot, R.A., Gubbens-Stibbe, J.M., Soudijn, W., Jacobson, K.A., Ijzerman, A.P., Danhof, M. , Quantification of the in vivo potency of the adenosine A2 receptor antagonist 8-(3-chlorostyryl)caffeine, J Pharmacol Exp Ther, vol. 275, no. 1, pp. 245-53.

Mathot, R.A., Cleton, A., Soudijn, W., AP, I.J., Danhof, M. , Pharmacokinetic modelling of the haemodynamic effects of the A2a adenosine receptor agonist CGS 21680C in conscious normotensive rats, Br J Pharmacol, vol. 114, no. 4, pp. 761-8.

Van der Wenden, E.M., Hartog-Witte, H.R., Roelen, H.C., von Frijtag Drabbe Kunzel, J.K., Pirovano, I.M., Mathot, R.A., Danhof, M., Van Aerschot, A., Lidaks, M.J., AP, I.J., , . et al., 8-substituted adenosine and theophylline-7-riboside analogues as potential partial agonists for the adenosine A1 receptor, Eur J Pharmacol, vol. 290, no. 3, pp. 189-99.

Appel, S., Mathot, R.A., Langemeijer, M.W., AP, I.J., Danhof, M. , Modelling of the pharmacodynamic interaction of an A1 adenosine receptor agonist and antagonist in vivo: N6-cyclopentyladenosine and 8-cyclopentyltheophylline, Br J Pharmacol, vol. 115, no. 7, pp. 1253-9.

Mathot, R.A., Van den Aarsen, B.C., Soudijn, W., Breimer, D.D., Ijzerman, A.P., Danhof, M. , Pharmacokinetic-pharmacodynamic modelling of the cardiovascular effects of R- and S-N6-phenylisopropyladenosine in conscious normotensive rats, J Pharmacol Exp Ther, vol. 273, no. 1, pp. 405-14.

1994

Mathot, R.A., Van den Aarsen, B.C., von Frijtag Drabble Kunzel, J.K., Danhof, M., Ijzerman, A.P. , Assessment of the enantiomeric purity of R- and S-N6-phenylisopropyladenosine (PIA): implications for adenosine receptor subclassification, Naunyn Schmiedebergs Arch Pharmacol, vol. 350, no. 1, pp. 109-12.

Mathot, R.A., van Schaick, E.A., Langemeijer, M.W., Soudijn, W., Breimer, D.D., Ijzerman, A.P., Danhof, M. , Pharmacokinetic-pharmacodynamic relationship of the cardiovascular effects of adenosine A1 receptor agonist N6-cyclopentyladenosine in the rat, J Pharmacol Exp Ther, vol. 268, no. 2, pp. 616-24.

AP, I.J., van der Wenden, E.M., von Frijtag Drabbe Kunzel, J.K., Mathot, R.A., Danhof, M., Borea, P.A., Varani, K. , Partial agonism of theophylline-7-riboside on adenosine receptors, Naunyn Schmiedebergs Arch Pharmacol, vol. 350, no. 6, pp. 638-45.

Irth, H., Cleton, A., Mathot, R.A., Danhof, M., AP, I.J., Tjaden, U.R., van der Greef, J. , Liquid chromatographic determination of the adenosine receptor agonist CGS 21680 in blood using on-line solid-phase extraction on a phenylboronic acid support and fluorescence detection, J Chromatogr B Biomed Appl, vol. 658, no. 1, pp. 207-12.

1993

Mathot, R.A., Appel, S., van Schaick, E.A., Soudijn, W., AP, I.J., Danhof, M. , High-performance liquid chromatography of the adenosine A1 agonist N6-cyclopentyladenosine and the A1 antagonist 8-cyclopentyltheophylline and its application in a pharmacokinetic study in rats, J Chromatogr, vol. 620, no. 1, pp. 113-20.

Danhof, M., Mandema, J.W., Hoogerkamp, A., Mathot, R.A. , Pharmacokinetic-pharmacodynamic modelling in pre-clinical investigations: principles and perspectives, Eur J Drug Metab Pharmacokinet, vol. 18, no. 1, pp. 41-7.

LACDR