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1999

Tuk, B., van Oostenbruggen, M.F., Herben, V.M., Mandema, J.W., Danhof, M. , Characterization of the pharmacodynamic interaction between parent drug and active metabolite in vivo: midazolam and alpha-OH-midazolam, J Pharmacol Exp Ther, vol. 289, no. 2, pp. 1067-74.

1998

Tuk, B., Herben, V.M., Mandema, J.W., Danhof, M. , Relevance of arteriovenous concentration differences in pharmacokinetic-pharmacodynamic modeling of midazolam, J Pharmacol Exp Ther, vol. 284, no. 1, pp. 202-7.

Della Paschoa, O.E., Mandema, J.W., Voskuyl, R.A., Danhof, M. , Pharmacokinetic-pharmacodynamic modeling of the anticonvulsant and electroencephalogram effects of phenytoin in rats, J Pharmacol Exp Ther, vol. 284, no. 2, pp. 460-6.

1997

Bol, C.J., AP, I.J., Danhof, M., Mandema, J.W. , Determination of dexmedetomidine in rat plasma by a sensitive [3H]clonidine radioreceptor assay, J Pharm Sci, vol. 86, no. 7, pp. 822-6.

Tuk, B., Danhof, M., Mandema, J.W. , The impact of arteriovenous concentration differences on pharmacodynamic parameter estimates, J Pharmacokinet Biopharm, vol. 25, no. 1, pp. 39-62.

Bol, C., Danhof, M., Stanski, D.R., Mandema, J.W. , Pharmacokinetic-pharmacodynamic characterization of the cardiovascular, hypnotic, EEG and ventilatory responses to dexmedetomidine in the rat, J Pharmacol Exp Ther, vol. 283, no. 3, pp. 1051-8.

1996

Hoogerkamp, A., Arends, R.H., Bomers, A.M., Mandema, J.W., Voskuyl, R.A., Danhof, M. , Pharmacokinetic/pharmacodynamic relationship of benzodiazepines in the direct cortical stimulation model of anticonvulsant effect, J Pharmacol Exp Ther, vol. 279, no. 2, pp. 803-12.

1995

de Lange, E.C., Bouw, M.R., Mandema, J.W., Danhof, M., de Boer, A.G., Breimer, D.D. , Application of intracerebral microdialysis to study regional distribution kinetics of drugs in rat brain, Br J Pharmacol, vol. 116, no. 5, pp. 2538-44.

Hoyo-Vadillo, C., Mandema, J.W., Danhof, M. , Pharmacodynamic interaction between midazolam and a low dose of ethanol in vivo, Life Sci, vol. 57, no. 4, pp. 325-33.

1993

Danhof, M., Mandema, J.W., Hoogerkamp, A., Mathot, R.A. , Pharmacokinetic-pharmacodynamic modelling in pre-clinical investigations: principles and perspectives, Eur J Drug Metab Pharmacokinet, vol. 18, no. 1, pp. 41-7.

Van Steveninck, A.L., Mandema, J.W., Tuk, B., Van Dijk, J.G., Schoemaker, H.C., Danhof, M., Cohen, A.F. , A comparison of the concentration-effect relationships of midazolam for EEG-derived parameters and saccadic peak velocity, Br J Clin Pharmacol, vol. 36, no. 2, pp. 109-15.

1992

Mandema, J.W., Danhof, M. , Electroencephalogram effect measures and relationships between pharmacokinetics and pharmacodynamics of centrally acting drugs, Clin Pharmacokinet, vol. 23, no. 3, pp. 191-215.

Hovinga, S., Stijnen, A.M., Langemeijer, M.W., Mandema, J.W., van Bezooijen, C.F., Danhof, M. , Pharmacokinetic-EEG effect relationship of midazolam in aging BN/BiRij rats, Br J Pharmacol, vol. 107, no. 1, pp. 171-7.

Danhof, M., Mandema, J.W. , Modelling of the pharmacodynamics and pharmacodynamic interactions of CNS active drugs, Int J Clin Pharmacol Ther Toxicol, vol. 30, no. 11, pp. 516-9.

Mandema, J.W., Tuk, B., van Steveninck, A.L., Breimer, D.D., Cohen, A.F., Danhof, M. , Pharmacokinetic-pharmacodynamic modeling of the central nervous system effects of midazolam and its main metabolite alpha-hydroxymidazolam in healthy volunteers, Clin Pharmacol Ther, vol. 51, no. 6, pp. 715-28.

Mandema, J.W., Kuck, M.T., Danhof, M. , Differences in intrinsic efficacy of benzodiazepines are reflected in their concentration-EEG effect relationship, Br J Pharmacol, vol. 105, no. 1, pp. 164-70.

Mandema, J.W., Tukker, E., Danhof, M. , In vivo characterization of the pharmacodynamic interaction of a benzodiazepine agonist and antagonist: midazolam and flumazenil, J Pharmacol Exp Ther, vol. 260, no. 1, pp. 36-44.

Mandema, J.W., Kuck, M.T., Danhof, M. , In vivo modeling of the pharmacodynamic interaction between benzodiazepines which differ in intrinsic efficacy, J Pharmacol Exp Ther, vol. 261, no. 1, pp. 56-61.

Mandema, J.W., Heijligers-Feijen, C.D., Tukker, E., De Boer, A.G., Danhof, M. , Modeling of the effect site equilibration kinetics and pharmacodynamics of racemic baclofen and its enantiomers using quantitative EEG effect measures, J Pharmacol Exp Ther, vol. 261, no. 1, pp. 88-95.

1991

Veng-Pedersen, P., Mandema, J.W., Danhof, M. , Biophase equilibration times, J Pharm Sci, vol. 80, no. 9, pp. 881-6.

Aarons, L., Mandema, J.W., Danhof, M. , A population analysis of the pharmacokinetics and pharmacodynamics of midazolam in the rat, J Pharmacokinet Biopharm, vol. 19, no. 5, pp. 485-96.

Veng-Pedersen, P., Mandema, J.W., Danhof, M. , A system approach to pharmacodynamics. III: An algorithm and computer program, COLAPS, for pharmacodynamic modeling, J Pharm Sci, vol. 80, no. 5, pp. 488-95.

Mandema, J.W., Tukker, E., Danhof, M. , Pharmacokinetic-pharmacodynamic modelling of the EEG effects of midazolam in individual rats: influence of rate and route of administration, Br J Pharmacol, vol. 102, no. 3, pp. 663-8.

Mandema, J.W., Veng-Pedersen, P., Danhof, M. , Estimation of amobarbital plasma-effect site equilibration kinetics. Relevance of polyexponential conductance functions, J Pharmacokinet Biopharm, vol. 19, no. 6, pp. 617-34.

Mandema, J.W., Sansom, L.N., Dios-Vieitez, M.C., Hollander-Jansen, M., Danhof, M. , Pharmacokinetic-pharmacodynamic modeling of the electroencephalographic effects of benzodiazepines. Correlation with receptor binding and anticonvulsant activity, J Pharmacol Exp Ther, vol. 257, no. 1, pp. 472-8.

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