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Universiteit Leiden

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1999

Knibbe, C.A., Koster, V.S., Aarts, L.P., Langemeijer, H.J., Danhof, M. , Pilot study in humans on the pharmacokinetics and safety of propofol 6% SAZN, Pharm World Sci, vol. 21, no. 5, pp. 239-40.

Knibbe, C.A., Voortman, H.J., Aarts, L.P., Kuks, P.F., Lange, R., Langemeijer, H.J., Danhof, M. , Pharmacokinetics, induction of anaesthesia and safety characteristics of propofol 6% SAZN vs propofol 1% SAZN and Diprivan-10 after bolus injection, Br J Clin Pharmacol, vol. 47, no. 6, pp. 653-60.

Cox, E.H., Langemeijer, M.W., Gubbens-Stibbe, J.M., Muir, K.T., Danhof, M. , The comparative pharmacodynamics of remifentanil and its metabolite, GR90291, in a rat electroencephalographic model, Anesthesiology, vol. 90, no. 2, pp. 535-44.

1998

van Schaick, E.A., Zuideveld, K.P., Tukker, H.E., Langemeijer, M.W., Ijzerman, A.P., Danhof, M. , Metabolic and cardiovascular effects of the adenosine A1 receptor agonist N6-(p-sulfophenyl)adenosine in diabetic Zucker rats: influence of the disease on the selectivity of action, J Pharmacol Exp Ther, vol. 287, no. 1, pp. 21-30.

Cox, E.H., Knibbe, C.A., Koster, V.S., Langemeijer, M.W., Tukker, E.E., Lange, R., Kuks, P.F., Langemeijer, H.J., Lie, A.H.L., Danhof, M. , Influence of different fat emulsion-based intravenous formulations on the pharmacokinetics and pharmacodynamics of propofol, Pharm Res, vol. 15, no. 3, pp. 442-8.

Cox, E.H., Langemeijer, M.W., Danhof, M. , Pharmacokinetic-pharmacodynamic modelling of the analgesic effect of alfentanil in the rat using tooth pulp evoked potentials, J Pharmacol Toxicol Methods, vol. 39, no. 1, pp. 19-27.

1997

van Schaick, E.A., de Greef, H.J., Langemeijer, M.W., Sheehan, M.J., AP, I.J., Danhof, M. , Pharmacokinetic-pharmacodynamic modelling of the anti-lipolytic and anti-ketotic effects of the adenosine A1-receptor agonist N6-(p-sulphophenyl)adenosine in rats, Br J Pharmacol, vol. 122, no. 3, pp. 525-33.

Van Schaick, E.A., Math-ot, R.A., Gubbens-Stibbe, J.M., Langemeijer, M.W., Roelen, H.C., Ijzerman, A.P., Danhof, M. , 8-Alkylamino-substituted analogs of N6-cyclopentyladenosine are partial agonists for the cardiovascular adenosine A1 receptors in vivo, J Pharmacol Exp Ther, vol. 283, no. 2, pp. 800-8.

1995

Appel, S., Mathot, R.A., Langemeijer, M.W., AP, I.J., Danhof, M. , Modelling of the pharmacodynamic interaction of an A1 adenosine receptor agonist and antagonist in vivo: N6-cyclopentyladenosine and 8-cyclopentyltheophylline, Br J Pharmacol, vol. 115, no. 7, pp. 1253-9.

1994

Mathot, R.A., van Schaick, E.A., Langemeijer, M.W., Soudijn, W., Breimer, D.D., Ijzerman, A.P., Danhof, M. , Pharmacokinetic-pharmacodynamic relationship of the cardiovascular effects of adenosine A1 receptor agonist N6-cyclopentyladenosine in the rat, J Pharmacol Exp Ther, vol. 268, no. 2, pp. 616-24.

1993

Stijnen, A.M., Hovinga, S., Langemeijer, M.W., Hoogerkamp, A., van Bezooijen, C.F., Danhof, M. , Increased sensitivity to the anticonvulsant effect of valproate in aging BN/BiRij rats, Pharm Res, vol. 10, no. 7, pp. 1046-51.

1992

Hovinga, S., Stijnen, A.M., Langemeijer, M.W., Mandema, J.W., van Bezooijen, C.F., Danhof, M. , Pharmacokinetic-EEG effect relationship of midazolam in aging BN/BiRij rats, Br J Pharmacol, vol. 107, no. 1, pp. 171-7.

Stijnen, A.M., Postel-Westra, I, Langemeijer, M.W., Hoogerkamp, A., Voskuyl, R.A., van Bezooijen, C.F., Danhof, M. , Pharmacodynamics of the anticonvulsant effect of oxazepam in aging BN/BiRij rats, Br J Pharmacol, vol. 107, no. 1, pp. 165-70.

1990

Dingemanse, J., Voskuyl, R.A., Langemeijer, M.W., Postel-Westra, I, Breimer, D.D., Meinardi, H., Danhof, M. , Pharmacokinetic-pharmacodynamic modelling of the anticonvulsant effect of oxazepam in individual rats, Br J Pharmacol, vol. 99, no. 1, pp. 53-8.

1989

Hollander-Jansen, M., Dingemanse, J., Langemeijer, M.W., Danhof, M. , Relationship between receptor occupancy at 37 degrees C and the anticonvulsant effect of flunitrazepam in rats, Pharm Res, vol. 6, no. 7, pp. 585-91.

1988

Dingemanse, J., Hutson, P.H., Langemeijer, M.W., Curzon, G., Danhof, M. , Application of serial sampling of cerebrospinal fluid in pharmacodynamic studies with a drug active in the CNS: heptabarbital concentrations at onset and offset of loss of righting reflex in rats, Neuropharmacology, vol. 27, no. 5, pp. 467-74.

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