LACDR

Universiteit Leiden

List
Filter

Found 17 results. Export: Tagged | XML

Filters: author is Ijzerman [Clear All Filters]

2005

Schaddelee, M.P., Collins, S.D., DeJongh, J., de Boer, A.G., Ijzerman, A.P., Danhof, M. , Pharmacokinetic/pharmacodynamic modelling of the anti-hyperalgesic and anti-nociceptive effect of adenosine A1 receptor partial agonists in neuropathic pain, Eur J Pharmacol, vol. 514, no. 2-3, pp. 131-40.

Schaddelee, M.P., Read, K.D., Cleypool, C.G., Ijzerman, A.P., Danhof, M., de Boer, A.G. , Brain penetration of synthetic adenosine A1 receptor agonists in situ: role of the rENT1 nucleoside transporter and binding to blood constituents, Eur J Pharm Sci, vol. 24, no. 1, pp. 59-66.

2004

Schaddelee, M.P., Dejongh, J., Collins, S.D., de Boer, A.G., Ijzerman, A.P., Danhof, M. , Population pharmacokinetic-pharmacodynamic modelling of the anti-hyperalgesic effect of 5'deoxy-N6-cylopentyladenosine in the mononeuropathic rat, Eur J Pharmacol, vol. 504, no. 1-2, pp. 7-15.

2003

Schaddelee, M.P., Voorwinden, H.L., Groenendaal, D., Hersey, A., Ijzerman, A.P., Danhof, M., De Boer, A.G. , Blood-brain barrier transport of synthetic adenosine A1 receptor agonists in vitro: structure transport relationships, Eur J Pharm Sci, vol. 20, no. 3, pp. 347-56.

Schaddelee, M.P., Voorwinden, H.L., van Tilburg, E.W., Pateman, T.J., Ijzerman, A.P., Danhof, M., de Boer, A.G. , Functional role of adenosine receptor subtypes in the regulation of blood-brain barrier permeability: possible implications for the design of synthetic adenosine derivatives, Eur J Pharm Sci, vol. 19, no. 1, pp. 13-22.

Bueters, T.J., Joosen, M.J., van Helden, H.P., Ijzerman, A.P., Danhof, M. , Adenosine A1 receptor agonist N6-cyclopentyladenosine affects the inactivation of acetylcholinesterase in blood and brain by sarin, J Pharmacol Exp Ther, vol. 304, no. 3, pp. 1307-13.

1999

Van der Graaf, P.H., Van Schaick, E.A., Visser, S.A., De Greef, H.J., Ijzerman, A.P., Danhof, M. , Mechanism-based pharmacokinetic-pharmacodynamic modeling of antilipolytic effects of adenosine A(1) receptor agonists in rats: prediction of tissue-dependent efficacy in vivo, J Pharmacol Exp Ther, vol. 290, no. 2, pp. 702-9.

1998

van Schaick, E.A., Zuideveld, K.P., Tukker, H.E., Langemeijer, M.W., Ijzerman, A.P., Danhof, M. , Metabolic and cardiovascular effects of the adenosine A1 receptor agonist N6-(p-sulfophenyl)adenosine in diabetic Zucker rats: influence of the disease on the selectivity of action, J Pharmacol Exp Ther, vol. 287, no. 1, pp. 21-30.

1997

Van Schaick, E.A., Math-ot, R.A., Gubbens-Stibbe, J.M., Langemeijer, M.W., Roelen, H.C., Ijzerman, A.P., Danhof, M. , 8-Alkylamino-substituted analogs of N6-cyclopentyladenosine are partial agonists for the cardiovascular adenosine A1 receptors in vivo, J Pharmacol Exp Ther, vol. 283, no. 2, pp. 800-8.

Van Der Graaf, P.H., Van Schaick, E.A., Math-ot, R.A., Ijzerman, A.P., Danhof, M. , Mechanism-based pharmacokinetic-pharmacodynamic modeling of the effects of N6-cyclopentyladenosine analogs on heart rate in rat: estimation of in vivo operational affinity and efficacy at adenosine A1 receptors, J Pharmacol Exp Ther, vol. 283, no. 2, pp. 809-16.

van Schaick, E.A., de Greef, H.J., Ijzerman, A.P., Danhof, M. , Physiological indirect effect modeling of the antilipolytic effects of adenosine A1-receptor agonists, J Pharmacokinet Biopharm, vol. 25, no. 6, pp. 673-94.

1996

Mathoot, R.A., Soudijn, W., Breimer, D.D., Ijzerman, A.P., Danhof, M. , Pharmacokinetic-haemodynamic relationships of 2-chloroadenosine at adenosine A1 and A2a receptors in vivo, Br J Pharmacol, vol. 118, no. 2, pp. 369-77.

Mathot, R.A., Wenden, E.M., Soudijn, W., Breimer, D.D., Ijzerman, A.P., Danhof, M. , Partial agonism of the nonselective adenosine receptor agonist 8-butylaminoadenosine at the A1 receptor in vivo, J Pharmacol Exp Ther, vol. 279, no. 3, pp. 1439-46.

1995

Mathot, R.A., Gubbens-Stibbe, J.M., Soudijn, W., Jacobson, K.A., Ijzerman, A.P., Danhof, M. , Quantification of the in vivo potency of the adenosine A2 receptor antagonist 8-(3-chlorostyryl)caffeine, J Pharmacol Exp Ther, vol. 275, no. 1, pp. 245-53.

Mathot, R.A., Van den Aarsen, B.C., Soudijn, W., Breimer, D.D., Ijzerman, A.P., Danhof, M. , Pharmacokinetic-pharmacodynamic modelling of the cardiovascular effects of R- and S-N6-phenylisopropyladenosine in conscious normotensive rats, J Pharmacol Exp Ther, vol. 273, no. 1, pp. 405-14.

1994

Mathot, R.A., Van den Aarsen, B.C., von Frijtag Drabble Kunzel, J.K., Danhof, M., Ijzerman, A.P. , Assessment of the enantiomeric purity of R- and S-N6-phenylisopropyladenosine (PIA): implications for adenosine receptor subclassification, Naunyn Schmiedebergs Arch Pharmacol, vol. 350, no. 1, pp. 109-12.

Mathot, R.A., van Schaick, E.A., Langemeijer, M.W., Soudijn, W., Breimer, D.D., Ijzerman, A.P., Danhof, M. , Pharmacokinetic-pharmacodynamic relationship of the cardiovascular effects of adenosine A1 receptor agonist N6-cyclopentyladenosine in the rat, J Pharmacol Exp Ther, vol. 268, no. 2, pp. 616-24.

LACDR