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Universiteit Leiden

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2009

Ploeger, B.A., Graaf, P.H., Danhof, M. , Incorporating receptor theory in mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling, Drug Metab Pharmacokinet, vol. 24, no. 1, pp. 3-15.

2007

Zuideveld, K.P., Van der Graaf, P.H., Peletier, L.A., Danhof, M. , Allometric scaling of pharmacodynamic responses: application to 5-Ht1A receptor mediated responses from rat to man, Pharm Res, vol. 24, no. 11, pp. 2031-9.

2005

Jonker, D.M., Visser, S.A., van der Graaf, P.H., Voskuyl, R.A., Danhof, M. , Towards a mechanism-based analysis of pharmacodynamic drug-drug interactions in vivo, Pharmacol Ther, vol. 106, no. 1, pp. 1-18.

2004

Zuideveld, K.P., Van der Graaf, P.H., Newgreen, D., Thurlow, R., Petty, N., Jordan, P., Peletier, L.A., Danhof, M. , Mechanism-based pharmacokinetic-pharmacodynamic modeling of 5-HT1A receptor agonists: estimation of in vivo affinity and intrinsic efficacy on body temperature in rats, J Pharmacol Exp Ther, vol. 308, no. 3, pp. 1012-20.

2003

Visser, S.A., Huntjens, D.R., van der Graaf, P.H., Peletier, L.A., Danhof, M. , Mechanism-based modeling of the pharmacodynamic interaction of alphaxalone and midazolam in rats, J Pharmacol Exp Ther, vol. 307, no. 2, pp. 765-75.

Visser, S.A., Wolters, F.L., van der Graaf, P.H., Peletier, L.A., Danhof, M. , Dose-dependent EEG effects of zolpidem provide evidence for GABA(A) receptor subtype selectivity in vivo, J Pharmacol Exp Ther, vol. 304, no. 3, pp. 1251-7.

Visser, S.A., Wolters, F.L., Gubbens-Stibbe, J.M., Tukker, E., Van Der Graaf, P.H., Peletier, L.A., Danhof, M. , Mechanism-based pharmacokinetic/pharmacodynamic modeling of the electroencephalogram effects of GABAA receptor modulators: in vitro-in vivo correlations, J Pharmacol Exp Ther, vol. 304, no. 1, pp. 88-101.

2002

Visser, S.A., Smulders, C.J., Reijers, B.P., Van der Graaf, P.H., Peletier, L.A., Danhof, M. , Mechanism-based pharmacokinetic-pharmacodynamic modeling of concentration-dependent hysteresis and biphasic electroencephalogram effects of alphaxalone in rats, J Pharmacol Exp Ther, vol. 302, no. 3, pp. 1158-67.

Visser, S.A., Gladdines, W.W., van der Graaf, P.H., Peletier, L.A., Danhof, M. , Neuroactive steroids differ in potency but not in intrinsic efficacy at the GABA(A) receptor in vivo, J Pharmacol Exp Ther, vol. 303, no. 2, pp. 616-26.

Zuideveld, K.P., van Gestel, A., Peletier, L.A., Van der Graaf, P.H., Danhof, M. , Pharmacokinetic-pharmacodynamic modelling of the hypothermic and corticosterone effects of the 5-HT1A receptor agonist flesinoxan, Eur J Pharmacol, vol. 445, no. 1-2, pp. 43-54.

Zuideveld, K.P., Treijtel, N., Maas, H.J., Gubbens-Stibbe, J.M., Peletier, L.A., van Der Graaf, P.H., Danhof, M. , A competitive interaction model predicts the effect of WAY-100,635 on the time course of R-(+)-8-hydroxy-2-(di-n-propylamino)tetralin-induced hypothermia, J Pharmacol Exp Ther, vol. 300, no. 1, pp. 330-8.

Zuideveld, K.P., Rusic-Pavletic, J., Maas, H.J., Peletier, L.A., Van der Graaf, P.H., Danhof, M. , Pharmacokinetic-pharmacodynamic modeling of buspirone and its metabolite 1-(2-pyrimidinyl)-piperazine in rats, J Pharmacol Exp Ther, vol. 303, no. 3, pp. 1130-7.

2001

Zuideveld, K.P., Maas, H.J., Treijtel, N., Hulshof, J., van der Graaf, P.H., Peletier, L.A., Danhof, M. , A set-point model with oscillatory behavior predicts the time course of 8-OH-DPAT-induced hypothermia, Am J Physiol Regul Integr Comp Physiol, vol. 281, no. 6, pp. R2059-71.

2000

Cleton, A., Odman, J., Van der Graaf, P.H., Ghijsen, W., Voskuyl, R., Danhof, M. , Mechanism-based modeling of functional adaptation upon chronic treatment with midazolam, Pharm Res, vol. 17, no. 3, pp. 321-7.

Garrido, M., Gubbens-Stibbe, J., Tukker, E., Cox, E., von Frijtag, J., Kunzel, D., A, I.J., Danhof, M., van der Graaf, P.H. , Pharmacokinetic-pharmacodynamic analysis of the EEG effect of alfentanil in rats following beta-funaltrexamine-induced mu-opioid receptor "knockdown" in vivo, Pharm Res, vol. 17, no. 6, pp. 653-9.

Zuideveld, K.P., Treijtel, N., Van der Graaf, P.H., Danhof, M. , Enantioselective high-performance liquid chromatographic analysis of the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin. Application to a pharmacokinetic-pharmacodynamic study in rats, J Chromatogr B Biomed Sci Appl, vol. 738, no. 1, pp. 67-73.

Visser, S.A., Smulders, C.J., Gladdines, W.W., Irth, H., van der Graaf, P.H., Danhof, M. , High-performance liquid chromatography of the neuroactive steroids alphaxalone and pregnanolone in plasma using dansyl hydrazine as fluorescent label: application to a pharmacokinetic-pharmacodynamic study in rats, J Chromatogr B Biomed Sci Appl, vol. 745, no. 2, pp. 357-63.

1999

Cleton, A., Van der Graaf, P.H., Ghijsen, W., Voskuyl, R., Danhof, M. , Mechanism-based modeling of adaptive changes in the pharmacodynamics of midazolam in the kindling model of epilepsy, Pharm Res, vol. 16, no. 11, pp. 1702-9.

Van der Graaf, P.H., Nilsson, J., Van Schaick, E.A., Danhof, M. , Multivariate quantitative structure-pharmacokinetic relationships (QSPKR) analysis of adenosine A1 receptor agonists in rat, J Pharm Sci, vol. 88, no. 3, pp. 306-12.

Van der Graaf, P.H., Van Schaick, E.A., Visser, S.A., De Greef, H.J., Ijzerman, A.P., Danhof, M. , Mechanism-based pharmacokinetic-pharmacodynamic modeling of antilipolytic effects of adenosine A(1) receptor agonists in rats: prediction of tissue-dependent efficacy in vivo, J Pharmacol Exp Ther, vol. 290, no. 2, pp. 702-9.

1998

Cox, E.H., Kerbusch, T., Van der Graaf, P.H., Danhof, M. , Pharmacokinetic-pharmacodynamic modeling of the electroencephalogram effect of synthetic opioids in the rat: correlation with the interaction at the mu-opioid receptor, J Pharmacol Exp Ther, vol. 284, no. 3, pp. 1095-103.

1997

Van der Graaf, P.H., Danhof, M. , Analysis of drug-receptor interactions in vivo: a new approach in pharmacokinetic-pharmacodynamic modelling, Int J Clin Pharmacol Ther, vol. 35, no. 10, pp. 442-6.

Van der Graaf, P.H., Danhof, M. , On the reliability of affinity and efficacy estimates obtained by direct operational model fitting of agonist concentration-effect curves following irreversible receptor inactivation, J Pharmacol Toxicol Methods, vol. 38, no. 2, pp. 81-5.

Van Der Graaf, P.H., Van Schaick, E.A., Math-ot, R.A., Ijzerman, A.P., Danhof, M. , Mechanism-based pharmacokinetic-pharmacodynamic modeling of the effects of N6-cyclopentyladenosine analogs on heart rate in rat: estimation of in vivo operational affinity and efficacy at adenosine A1 receptors, J Pharmacol Exp Ther, vol. 283, no. 2, pp. 809-16.

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