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Universiteit Leiden

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1991

Koopmans, R., Dingemanse, J., Danhof, M., Horsten, G.P., van Boxtel, C.J. , The influence of dosage time of midazolam on its pharmacokinetics and effects in humans, Clin Pharmacol Ther, vol. 50, no. 1, pp. 16-24.

1990

Dingemanse, J., Hameter, B.M., Danhof, M. , Pharmacodynamics of tolerance development to the anesthetic and anticonvulsant effects of phenobarbital in rats, J Pharm Sci, vol. 79, no. 3, pp. 207-11.

Dingemanse, J., Voskuyl, R.A., Langemeijer, M.W., Postel-Westra, I, Breimer, D.D., Meinardi, H., Danhof, M. , Pharmacokinetic-pharmacodynamic modelling of the anticonvulsant effect of oxazepam in individual rats, Br J Pharmacol, vol. 99, no. 1, pp. 53-8.

1989

Dingemanse, J., van Bree, J.B., Danhof, M. , Pharmacokinetic modeling of the anticonvulsant action of phenobarbital in rats, J Pharmacol Exp Ther, vol. 249, no. 2, pp. 601-8.

Voskuyl, R.A., Dingemanse, J., Danhof, M. , Determination of the threshold for convulsions by direct cortical stimulation, Epilepsy Res, vol. 3, no. 2, pp. 120-9.

Hollander-Jansen, M., Dingemanse, J., Langemeijer, M.W., Danhof, M. , Relationship between receptor occupancy at 37 degrees C and the anticonvulsant effect of flunitrazepam in rats, Pharm Res, vol. 6, no. 7, pp. 585-91.

1988

Dingemanse, J., Hutson, P.H., Langemeijer, M.W., Curzon, G., Danhof, M. , Application of serial sampling of cerebrospinal fluid in pharmacodynamic studies with a drug active in the CNS: heptabarbital concentrations at onset and offset of loss of righting reflex in rats, Neuropharmacology, vol. 27, no. 5, pp. 467-74.

Dingemanse, J., Polhuijs, M., Danhof, M. , Altered pharmacokinetic-pharmacodynamic relationship of heptabarbital in experimental renal failure in rats, J Pharmacol Exp Ther, vol. 246, no. 1, pp. 371-6.

Koopmans, R., Dingemanse, J., Danhof, M., Horsten, G.P., van Boxtel, C.J. , Pharmacokinetic-pharmacodynamic modeling of midazolam effects on the human central nervous system, Clin Pharmacol Ther, vol. 44, no. 1, pp. 14-22.

Dingemanse, J., Thomassen, D., Mentink, B.H., Danhof, M. , Strategy to assess the role of (inter)active metabolites in pharmacodynamic studies in-vivo: a model study with heptabarbital, J Pharm Pharmacol, vol. 40, no. 8, pp. 552-7.

Dingemanse, J., Sollie, F.A., Breimer, D.D., Danhof, M. , Pharmacokinetic modeling of the anticonvulsant response of oxazepam in rats using the pentylenetetrazol threshold concentration as pharmacodynamic measure, J Pharmacokinet Biopharm, vol. 16, no. 2, pp. 203-28.

Dingemanse, J., Danhof, M., Breimer, D.D. , Pharmacokinetic-pharmacodynamic modeling of CNS drug effects: an overview, Pharmacol Ther, vol. 38, no. 1, pp. 1-52.

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