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- 2000
Mechanism-based modeling of functional adaptation upon chronic treatment with midazolam,
Pharm Res, vol. 17, no. 3, pp. 321-7.
Effect of amygdala kindling on the central nervous system effects of tiagabine: EEG effects versus brain GABA levels,
Br J Pharmacol, vol. 130, no. 5, pp. 1037-44.
Pharmacokinetic-pharmacodynamic modelling of tiagabine CNS effects upon chronic treatment in rats: lack of change in concentration-EEG effect relationship,
Eur J Pharm Sci, vol. 12, no. 2, pp. 141-50.
- 1999
Mechanism-based modeling of adaptive changes in the pharmacodynamics of midazolam in the kindling model of epilepsy,
Pharm Res, vol. 16, no. 11, pp. 1702-9.
Rate of change of blood concentrations is a major determinant of the pharmacodynamics of midazolam in rats,
Br J Pharmacol, vol. 127, no. 1, pp. 227-35.
Application of a combined "effect compartment/indirect response model" to the central nervous system effects of tiagabine in the rat,
J Pharmacokinet Biopharm, vol. 27, no. 3, pp. 301-23.
Stereoselective central nervous system effects of the R- and S-isomers of the GABA uptake blocker N-(4, 4-di-(3-methylthien-2-yl)but-3-enyl) nipecotic acid in the rat,
Br J Pharmacol, vol. 128, no. 8, pp. 1651-8.
- 1998
Adaptive changes in the pharmacodynamics of midazolam in different experimental models of epilepsy: kindling, cortical stimulation and genetic absence epilepsy,
Br J Pharmacol, vol. 125, no. 4, pp. 615-20.
- 1995
Pharmacokinetic modelling of the haemodynamic effects of the A2a adenosine receptor agonist CGS 21680C in conscious normotensive rats,
Br J Pharmacol, vol. 114, no. 4, pp. 761-8.
- 1994
Liquid chromatographic determination of the adenosine receptor agonist CGS 21680 in blood using on-line solid-phase extraction on a phenylboronic acid support and fluorescence detection,
J Chromatogr B Biomed Appl, vol. 658, no. 1, pp. 207-12.
