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Universiteit Leiden

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1997

de Lange, E.C., Danhof, M., de Boer, A.G., Breimer, D.D. , Methodological considerations of intracerebral microdialysis in pharmacokinetic studies on drug transport across the blood-brain barrier, Brain Res Brain Res Rev, vol. 25, no. 1, pp. 27-49.

Tuk, B., Oberye, J.J., Pieters, M.S., Schoemaker, R.C., Kemp, B., van Gerven, J., Danhof, M., Kamphuisen, H.A., Cohen, A.F., Breimer, D.D., Peck, C.C. , Pharmacodynamics of temazepam in primary insomnia: assessment of the value of quantitative electroencephalography and saccadic eye movements in predicting improvement of sleep, Clin Pharmacol Ther, vol. 62, no. 4, pp. 444-52.

Auler Junior, J.O., Espada, E.B., Crivelli, E., Quintavalle, T.B., Kurata, A., Stolf, N.A., Issy, A.M., Paschoa, O.E., Danhof, M., Breimer, D.D., Chamone, D.A., Santos, S.R. , Diclofenac plasma protein binding: PK-PD modelling in cardiac patients submitted to cardiopulmonary bypass, Braz J Med Biol Res, vol. 30, no. 3, pp. 369-74.

Breimer, D.D., Danhof, M. , Relevance of the application of pharmacokinetic-pharmacodynamic modelling concepts in drug development. The "wooden shoe' paradigm, Clin Pharmacokinet, vol. 32, no. 4, pp. 259-67.

1996

Mathoot, R.A., Soudijn, W., Breimer, D.D., Ijzerman, A.P., Danhof, M. , Pharmacokinetic-haemodynamic relationships of 2-chloroadenosine at adenosine A1 and A2a receptors in vivo, Br J Pharmacol, vol. 118, no. 2, pp. 369-77.

Mathot, R.A., Wenden, E.M., Soudijn, W., Breimer, D.D., Ijzerman, A.P., Danhof, M. , Partial agonism of the nonselective adenosine receptor agonist 8-butylaminoadenosine at the A1 receptor in vivo, J Pharmacol Exp Ther, vol. 279, no. 3, pp. 1439-46.

1995

de Lange, E.C., Bouw, M.R., Mandema, J.W., Danhof, M., de Boer, A.G., Breimer, D.D. , Application of intracerebral microdialysis to study regional distribution kinetics of drugs in rat brain, Br J Pharmacol, vol. 116, no. 5, pp. 2538-44.

de Lange, E.C., Hesselink, M.B., Danhof, M., de Boer, A.G., Breimer, D.D. , The use of intracerebral microdialysis to determine changes in blood-brain barrier transport characteristics, Pharm Res, vol. 12, no. 1, pp. 129-33.

de Lange, E.C., Danhof, M., Zurcher, C., de Boer, A.G., Breimer, D.D. , Repeated microdialysis perfusions: periprobe tissue reactions and BBB permeability, Brain Res, vol. 702, no. 1-2, pp. 261-5.

de Lange, E.C., de Vries, J.D., Zurcher, C., Danhof, M., de Boer, A.G., Breimer, D.D. , The use of intracerebral microdialysis for the determination of pharmacokinetic profiles of anticancer drugs in tumor-bearing rat brain, Pharm Res, vol. 12, no. 12, pp. 1924-31.

Mathot, R.A., Van den Aarsen, B.C., Soudijn, W., Breimer, D.D., Ijzerman, A.P., Danhof, M. , Pharmacokinetic-pharmacodynamic modelling of the cardiovascular effects of R- and S-N6-phenylisopropyladenosine in conscious normotensive rats, J Pharmacol Exp Ther, vol. 273, no. 1, pp. 405-14.

1994

Mathot, R.A., van Schaick, E.A., Langemeijer, M.W., Soudijn, W., Breimer, D.D., Ijzerman, A.P., Danhof, M. , Pharmacokinetic-pharmacodynamic relationship of the cardiovascular effects of adenosine A1 receptor agonist N6-cyclopentyladenosine in the rat, J Pharmacol Exp Ther, vol. 268, no. 2, pp. 616-24.

de Lange, E.C., Danhof, M., de Boer, A.G., Breimer, D.D. , Critical factors of intracerebral microdialysis as a technique to determine the pharmacokinetics of drugs in rat brain, Brain Res, vol. 666, no. 1, pp. 1-8.

1993

Van Bree, J.B., De Boer, A.G., Danhof, M., Breimer, D.D. , Drug transport across the blood-brain barrier. III. Mechanisms and methods to improve drug delivery to the central nervous system, Pharm World Sci, vol. 15, no. 1, pp. 2-9.

de Lange, E.C., Danhof, M., de Boer, A.G., Breimer, D.D. , The use of intracerebral microdialysis to study blood-brain barrier transport in health, after modification and in disease, Adv Exp Med Biol, vol. 331, pp. 257-62.

1992

Van Bree, J.B., De Boer, A.G., Danhof, M., Breimer, D.D. , Drug transport across the blood--brain barrier. I. Anatomical and physiological aspects, Pharm Weekbl Sci, vol. 14, no. 5, pp. 305-10.

Mandema, J.W., Tuk, B., van Steveninck, A.L., Breimer, D.D., Cohen, A.F., Danhof, M. , Pharmacokinetic-pharmacodynamic modeling of the central nervous system effects of midazolam and its main metabolite alpha-hydroxymidazolam in healthy volunteers, Clin Pharmacol Ther, vol. 51, no. 6, pp. 715-28.

Van Bree, J.B., De Boer, A.G., Danhof, M., Breimer, D.D. , Drug transport across the blood-brain barrier. II. Experimental techniques to study drug transport, Pharm Weekbl Sci, vol. 14, no. 6, pp. 338-48.

Soons, P.A., van den Berg, G., Danhof, M., van Brummelen, P., Jansen, J.B., Lamers, C.B., Breimer, D.D. , Influence of single- and multiple-dose omeprazole treatment on nifedipine pharmacokinetics and effects in healthy subjects, Eur J Clin Pharmacol, vol. 42, no. 3, pp. 319-24.

1991

de Boer, A., Stiekema, J.C., Danhof, M., van Dinther, T.G., Boeijinga, J.K., Cohen, A.F., Breimer, D.D. , Studies of interaction of a low-molecular-weight heparinoid (Org 10172) with cloxacillin and ticarcillin in healthy male volunteers, Antimicrob Agents Chemother, vol. 35, no. 10, pp. 2110-5.

Breimer, L.T., Burm, A.G., Danhof, M., Hennis, P.J., Vletter, A.A., de Voogt, J.W., Spierdijk, J., Bovill, J.G. , Pharmacokinetic-pharmacodynamic modelling of the interaction between flumazenil and midazolam in volunteers by aperiodic EEG analysis, Clin Pharmacokinet, vol. 20, no. 6, pp. 497-508.

Breimer, L.T., Hennis, P.J., Burm, A.G., Danhof, M., Bovill, J.G., Spierdijk, J., Vletter, A.A. , Pharmacokinetics and EEG effects of flumazenil in volunteers, Clin Pharmacokinet, vol. 20, no. 6, pp. 491-6.

de Boer, A., Stiekema, J.C., Danhof, M., Breimer, D.D. , Influence of chlorthalidone on the pharmacokinetics and pharmacodynamics of Org 10172 (Lomoparan), a low molecular weight heparinoid, in healthy volunteers, J Clin Pharmacol, vol. 31, no. 7, pp. 611-7.

De Boer, A., Stiekema, J.C., Danhof, M., Breimer, D.D. , The influence of Org 10172, a low molecular weight heparinoid, on antipyrine metabolism and the effect of enzyme induction on the response to Org 10172, Br J Clin Pharmacol, vol. 32, no. 1, pp. 23-9.

van Bree, J.B., Heijligers-Feijen, C.D., de Boer, A.G., Danhof, M., Breimer, D.D. , Stereoselective transport of baclofen across the blood-brain barrier in rats as determined by the unit impulse response methodology, Pharm Res, vol. 8, no. 2, pp. 259-62.

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