Amoxicillin pharmacokinetics in pregnant women with preterm premature rupture of the membranes

Publication Type:

Journal Article

Authors:

Muller, A.E.; DeJongh, J.; Oostvogel, P.M.; Voskuyl, R.A.; Dorr, P.J.; Danhof, M.; Mouton, J.W.

Source:

Am J Obstet Gynecol, Volume 198, Number 1, p.108 e1-6 (2008)

ISBN:

1097-6868 (Electronic)

DOI Name (links to online publication)

10.1016/j.ajog.2007.05.018

Keywords:

Adult; Amoxicillin/administration; &; dosage/*pharmacokinetics; Case-Control Studies; Chromatography; High Pressure Liquid; Dose-Response Relationship; Drug; Drug Administration Schedule; Female; Fetal Membranes; Premature Rupture/diagnosis/*drug therap

Abstract:

OBJECTIVE: This study was undertaken to study the pharmacokinetics of intravenously administered amoxicillin in pregnant women with preterm premature rupture of the membranes (PPROM). STUDY DESIGN: Healthy women with PPROM were recruited and treated with amoxicillin (2 g initially and 1 g subsequently). Blood samples were obtained from the opposite arm and concentrations determined with the use of high-pressure liquid chromatography. Nonlinear mixed-effects modeling was performed in nonlinear mixed effect (population) modeling. RESULTS: The pharmacokinetics of 17 patients was described by a 3-compartment model. Clearance and volume of distribution at steady state were 22.8 L/h and 21.4 L/h, respectively, similar to values in nonpregnant individuals. There was little variability between patients. No relationship was observed between values of individual pharmacokinetic parameters and various covariates. CONCLUSION: The pharmacokinetics of amoxicillin in pregnant patients with PPROM similar to nonpregnant individuals. Given the small interindividual variability in pharmacokinetics, no dose adjustments are required to account for differences between subjects under normal circumstances.