Pharmacokinetic research is fundamentally important for the development, registration and application of new drugs. This post-doctoral course discusses the most important novel approaches in human-drug relations:

• Absorption, in relation to drug delivery pathways and forms;
• Distribution, a.o. lipid binding, blood-brain barrier and placenta passage;
• Excretion, through urine, bile, saliva and breast milk;
• Biotransformation, i.e. the various Cytochrome P450 enzymes and the origin of genetically induced polymorphisms, conversion speed, induction, inhibition, saturation and interactions.

Following a general introduction, these processes will be discussed according to pharmacokinetic parameter clearance, partition volume, and half-life. With a problem-orientated approach, the focus will be on the interpretation of pharmacokinetic data, both in healthy volunteers, as well as in patients (i.e. suffering from kidney insufficiency and liver illness). Additionally, the role of pharmacokinetic studies in drug registration will be addressed. The course will be concluded with a discussion on the relations between pharmacokinetics and pharmacodynamics. This course will be provided in the form of lectures, alternated with practical examples and cases studies, with ample possibility for discussion.
 
Target Audience

This post-doctoral course is especially tailored for the needs of researchers from the pharmaceutical industry, who often encounter pharmacokinetic data and its interpretation for registration purposes, but is also highly recommended to anyone who on a regular basis is involved with the evaluation of the functionality and the fortunes of drugs.

Course Fee:
 €1150,- including course ma¬terials, consumptions during the breaks, 3x lunch, 2x diner, excluding hotel accommodation.

Hotel Accomodation:
€190,- for two nights (including breakfasts). 

PhD-students:
A maximum of 5 PhD-students can register for a reduced fee. A support letter of the supervisor has to be included upon registration.
 
Registration and payment:
There is a maximum of 30 participants, so please send in your registration as soon as possible. Upon receipt of the registration form, we will send a confirmation letter with the invoice attached. Payment has to be fulfilled before the start of the course.

Cancellations:
Cancellations made before August 1st, 2010, are free of cost.
After August 1st, 2010, the following payments are required:
- Between August 1st, and September 1st, 2010: 50 % of the course fee.
- After September 1st, 2010: 100 % of the  course fee.
Swapping registered participants is possible until the start of the course.

Registration form and full program: